ArticleProceedings of the National Academy of Sciences of the United States of America1994
E-cadherin distribution in interleukin 6-induced cell-cell separation of ductal breast carcinoma cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 30 citations in OpenAlex.
- Interleukin-6 at the Host-Tumor Interface: STAT3 in Biomolecular Condensates in Cancer Cells.Cells · 2022Review
- IL-6-mediated cross-talk between human preadipocytes and ductal carcinoma in situ in breast cancer progression.Journal of experimental & clinical cancer research : CR · 2018Article
- Microfluidic co-culture system for cancer migratory analysis and anti-metastatic drugs screening.Scientific reports · 2016Article
- Il-6 signaling between ductal carcinoma in situ cells and carcinoma-associated fibroblasts mediates tumor cell growth and migration.BMC cancer · 2015Article
- Role of Procalcitonin and Interleukin-6 in Predicting Cancer, and Its Progression Independent of Infection.PloS one · 2015Article
- Article
- Lymphocyte recruitment into the tumor site is altered in patients with MSI-H colon cancer.Familial cancer · 2009Article
- Characterization of the E-cadherin/catenin complex in colorectal carcinoma cell lines.International journal of experimental pathology · 2004Article
- Regulatory effect of interleukin-4 and interleukin-13 on colon cancer cell adhesion.British journal of cancer · 2000Article
- Induction of three-dimensional assembly of human liver cells by simulated microgravity.In vitro cellular & developmental biology. Animal · 1999Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
E-cadherin is expressed in both the ZR-75-1-Tx and the ZR-75-1-Ro sublines of ductal breast carcinoma cells and is concentrated at cell-cell borders as shown by immunocytochemical examination. Free cell borders generally show no or little staining. The localized decrease in E-cadherin expression observed after interleukin 6 (IL-6) treatment of either subline correlates with the increase in free cell borders as IL-6 causes cell-cell separation. As we previously reported, many IL-6-treated ZR-75-1-Tx cells round up and detach from the substratum while ZR-75-1-Ro cells remain adherent and display prominent processes. The results are consistent with the view that E-cadherin expression is not responsible for the marked difference in the IL-6-induced phenotypes in these cell lines, although the localized decrease may play a role in cell-cell separation. ZR-75-1-Tx cells are deficient in desmosomes and show a wider intercellular space than ZR-75-1-Ro cells. Alternative mechanisms involving different aspects of the interlinked cytoskeletal and cell adhesion structures are considered to account for the IL-6-induced antimorphogenetic effect.
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Registered trials
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