ArticleProceedings of the National Academy of Sciences of the United States of America1994
Alpha 1(XVIII), a collagen chain with frequent interruptions in the collagenous sequence, a distinct tissue distribution, and homology with type XV collagen.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- Exercise increases serum endostatin levels in female and male patients with diabetes and controls.Cardiovascular diabetology · 2014Trial
- Altered Extracellular Matrix as an Alternative Risk Factor for Epileptogenicity in Brain Tumors.Biomedicines · 2022Review
- Endostatin in Renal and Cardiovascular Diseases.Kidney diseases (Basel, Switzerland) · 2021Review
- Collagen XV, a multifaceted multiplexin present across tissues and species.Matrix biology plus · 2020Article
- Wnt Binding Affinity Prediction for Putative Frizzled-Type Cysteine-Rich Domains.International journal of molecular sciences · 2019Article
- Endostatin and transglutaminase 2 are involved in fibrosis of the aging kidney.Kidney international · 2016Article
- The Role of Collagens in Peripheral Nerve Myelination and Function.Molecular neurobiology · 2015Review
- Proteoglycan form and function: A comprehensive nomenclature of proteoglycans.Matrix biology : journal of the International Society for Matrix Biology · 2015Review
- Elective orthopedic and cardiopulmonary bypass surgery causes a reduction in serum endostatin levels.European journal of medical research · 2014Article
- Basement membrane zone collagens XV and XVIII/proteoglycans mediate leukocyte influx in renal ischemia/reperfusion.PloS one · 2014Article
- Endostatin lowers blood pressure via nitric oxide and prevents hypertension associated with VEGF inhibition.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Corneal neovascularization and the utility of topical VEGF inhibition: ranibizumab (Lucentis) vs bevacizumab (Avastin).The ocular surface · 2012Review
- Genotype analysis of the human endostatin variant p.D104N in benign and malignant adrenocortical tumors.Clinics (Sao Paulo, Brazil) · 2012Article
- Lipid raft redox signaling: molecular mechanisms in health and disease.Antioxidants & redox signaling · 2011Review
- Lack of collagen XVIII long isoforms affects kidney podocytes, whereas the short form is needed in the proximal tubular basement membrane.The Journal of biological chemistry · 2011Article
- Crystal structure of the human collagen XV trimerization domain: a potent trimerizing unit common to multiplexin collagens.Matrix biology : journal of the International Society for Matrix Biology · 2011Article
- Recombinant human collagen XV regulates cell adhesion and migration.The Journal of biological chemistry · 2010Article
- Crystal structure of human collagen XVIII trimerization domain: A novel collagen trimerization Fold.Journal of molecular biology · 2009Article
- A cryptic frizzled module in cell surface collagen 18 inhibits Wnt/beta-catenin signaling.PloS one · 2008Article
- Critical role of lipid raft redox signaling platforms in endostatin-induced coronary endothelial dysfunction.Arteriosclerosis, thrombosis, and vascular biology · 2008Article
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2 authors.
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Abstract
We report on the isolation of mouse cDNA clones which encode a collagenous sequence designated here as the alpha 1 chain of type XVIII collagen. The overlapping clones cover 2.8 kilobases and encode an open reading frame of 928 amino acid residues comprising a putative signal peptide of 25 residues, an amino-terminal noncollagenous domain of 301 residues, and a primarily collagenous stretch of 602 residues. The clones do not cover the carboxyl-terminal end of the polypeptide, since the translation stop codon is absent. Characteristic of the deduced polypeptide is the possession of eight noncollagenous interruptions varying in length from 10 to 24 residues in the collagenous amino acid sequence. Other features include the presence of several putative sites for both N-linked glycosylation and O-linked glycosaminoglycan attachment and homology of the amino-terminal noncollagenous domain with thrombospondin. It is of particular interest that five of the eight collagenous sequences of type XVIII show homology to the previously reported type XV collagen, suggesting that the two form a distinct subgroup among the diverse family of collagens. Northern blot hybridization analysis revealed a striking tissue distribution for type XVIII collagen mRNAs, as the clones hybridized strongly with mRNAs of 4.3 and 5.3 kilobases that were present only in lung and liver of the eight mouse tissues studied.
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