ArticleThe Journal of clinical investigation1994
Vascular mechanisms of cyclosporin-induced hypertension in the rat.
Article in The Journal of clinical investigation, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 113 citations in OpenAlex.
- Trial
- Safety and tolerability of cyclosporin a in severe traumatic brain injury patients: results from a prospective randomized trial.Journal of neurotrauma · 2009Trial
- Role of hypertension in kidney transplant recipients.Journal of human hypertension · 2021Review
- Dehydroxymethylepoxyquinomicin, a novel nuclear factor-κB inhibitor, prevents the development of cyclosporine A nephrotoxicity in a rat model.BMC pharmacology & toxicology · 2020Article
- Arterial Stiffness in the Heart Disease of CKD.Journal of the American Society of Nephrology : JASN · 2019Review
- Impact of immunosuppressive therapy on arterial stiffness in kidney transplantation: are all treatments the same?Clinical kidney journal · 2018Article
- Effect of UMOD genotype on long-term graft survival after kidney transplantation in patients treated with cyclosporine-based therapy.The pharmacogenomics journal · 2018Article
- Myeloid-Derived Suppressor Cells Ameliorate Cyclosporine A-Induced Hypertension in Mice.Hypertension (Dallas, Tex. : 1979) · 2018Article
- Deletion of mineralocorticoid receptors in smooth muscle cells blunts renal vascular resistance following acute cyclosporine administration.Kidney international · 2016Article
- Assessment and management of hypertension in transplant patients.Journal of the American Society of Nephrology : JASN · 2015Review
- The course of incidental intraorbital cavernous hemangioma in a patient with myasthenia gravis treated with cyclosporine: a case report.Case reports in neurology · 2014Article
- Conversion to sirolimus ameliorates cyclosporine-induced nephropathy in the rat: focus on serum, urine, gene, and protein renal expression biomarkers.BioMed research international · 2014Article
- Hypertension after kidney transplantation: a pathophysiologic approach.Current hypertension reports · 2013Review
- Regional haemodynamic effects of cyclosporine A, tacrolimus and sirolimus in conscious rats.British journal of pharmacology · 2004Article
- Review
- Plasma kinetics of chylomicron-like emulsion in renal transplant patients receiving cyclosporin-based immunosuppression.Clinical cardiology · 1998Article
- Effect of cyclosporin A and analogues on cytosolic calcium and vasoconstriction: possible lack of relationship to immunosuppressive activity.British journal of pharmacology · 1996Article
- Enhanced development of atherosclerosis in cholesterol-fed rabbits by suppression of cell-mediated immunity.The Journal of clinical investigation · 1995Article
- Mevalonate availability affects human and rat resistance vessel function.The Journal of clinical investigation · 1995Article
- Pathogenesis of calcineurin inhibitor-induced hypertension.Journal of nephrologyReview
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Numerous studies have explored the pathogenesis of cyclosporin A (CysA)-induced hypertension; however, none has assessed the impact of CysA treatment on resistance arteries in the setting of elevated blood pressure. Therefore, we studied the chronic effect of CysA on rat mesenteric artery resistance vessels (ex vivo). CysA (25 mg/kg per d for 7 d), but not vehicle, significantly raised systolic blood pressure (13.4 +/- 2.2 mmHg, P < 0.003, n = 9 per group). The resistance vessels from CysA-treated rats showed a small but significant decrease in norepinephrine sensitivity (P < 0.03) and a pronounced decrease in endothelium-dependent and -independent relaxation (P < 0.001) compared to controls. Endothelin-1 sensitivity tended to be diminished (P = 0.07). The direct (in vitro) effect of CysA was subsequently evaluated in resistance vessels from nontreated animals (n = 8) and exposed to CysA (2 micrograms/ml) for 24 h. As observed in vivo, CysA significantly decreased endothelium-dependent and -independent relaxations (P < 0.05) and attenuated norepinephrine sensitivity (P = 0.06). Methylene blue, a nitric oxide quencher, significantly inhibited the acetylcholine-induced relaxation in control, but not in CysA vessels, suggesting a selective action of CysA on the nitric oxide pathway. We conclude that CysA-induced hypertension is the consequence of a primary effect on resistance vessel relaxation, not increased vasoconstriction, as previously suggested.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.