ArticleThe Journal of clinical investigation1994
Secretion-recapture process of apolipoprotein E in hepatic uptake of chylomicron remnants in transgenic mice.
Article in The Journal of clinical investigation, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 56 citations in OpenAlex.
- Vitamin K nutrition, metabolism, and requirements: current concepts and future research.Advances in nutrition (Bethesda, Md.) · 2012Review
- Human LDL receptor enhances sequestration of ApoE4 and VLDL remnants on the surface of hepatocytes but not their internalization in mice.Arteriosclerosis, thrombosis, and vascular biology · 2008Article
- Atherogenic remnant lipoproteins: role for proteoglycans in trapping, transferring, and internalizing.The Journal of clinical investigation · 2007Article
- Lipoprotein lipase- and hepatic triglyceride lipase- promoted very low density lipoprotein degradation proceeds via an apolipoprotein E-dependent mechanism.Journal of lipid research · 2000Article
- Dissection of the complex role of apolipoprotein E in lipoprotein metabolism and atherosclerosis using mouse models.Current atherosclerosis reports · 1999Review
- Cholesterol lowering in low density lipoprotein receptor knockout mice overexpressing apolipoprotein E.The Journal of clinical investigation · 1998Article
- Hepatic apo E expression is required for remnant lipoprotein clearance in the absence of the low density lipoprotein receptor.The Journal of clinical investigation · 1998Article
- Nascent very-low-density lipoprotein triacylglycerol hydrolysis by lipoprotein lipase is inhibited by apolipoprotein E in a dose-dependent manner.The Biochemical journal · 1997Article
- In the absence of the low density lipoprotein receptor, human apolipoprotein C1 overexpression in transgenic mice inhibits the hepatic uptake of very low density lipoproteins via a receptor-associated protein-sensitive pathway.The Journal of clinical investigation · 1996Article
- Effective treatment of familial hypercholesterolaemia in the mouse model using adenovirus-mediated transfer of the VLDL receptor gene.Nature genetics · 1996Article
- Inhibition of diet-induced atheroma formation in transgenic mice expressing apolipoprotein E in the arterial wall.The Journal of clinical investigation · 1995Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate the role of apoE in hepatic uptake of chylomicron remnants, we studied chylomicron metabolism in transgenic mice overexpressing apoE in the liver. Plasma clearance of injected 125I-labeled human chylomicrons was fivefold faster in transgenic mice than in controls. Immunohistochemistry demonstrated that apoE was specifically localized at the basolateral surface of hepatocytes from fasted transgenic mice. After injection of a large amount of chylomicrons, the density of the cell surface apoE was markedly reduced and vesicular staining was observed in the cytoplasm, suggesting that the cell surface apoE was used for hepatic endocytosis of chylomicrons and remnants. Polyacrylamide gel analysis of chylomicrons and remnants that had been reisolated from plasma and from liver membrane after the injection of chylomicrons showed the particles to be enriched with apoE mainly after their influx into the liver rather than during their residence in plasma. These results provide strong evidence for the secretion-recapture process of apoE, whereby chylomicron remnants enter the sinusoidal space, acquire apoE molecules, and subsequently are endocytosed. Data from experiments with very low density lipoprotein and LDL showed that this system is specific for chylomicron remnants.
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