ArticleThe Journal of clinical investigation1994
Expression of the mouse corticotropin-releasing hormone gene in vivo and targeted inactivation in embryonic stem cells.
Article in The Journal of clinical investigation, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 113 citations in OpenAlex.
- Metabolic and behavioral alterations associated with viral vector-mediated toxicity in the paraventricular hypothalamic nucleus.Bioscience reports · 2024Article
- Hypothalamic Regulation of Corticotropin-Releasing Factor under Stress and Stress Resilience.International journal of molecular sciences · 2021Review
- Neuroendocrine control of appetite and metabolism.Experimental & molecular medicine · 2021Review
- Involvement of Corticotropin-Releasing Factor and Receptors in Immune Cells in Irritable Bowel Syndrome.Frontiers in endocrinology · 2018Review
- Loss of hypothalamic corticotropin-releasing hormone markedly reduces anxiety behaviors in mice.Molecular psychiatry · 2017Article
- Administration of antenatal glucocorticoids and postnatal surfactant ameliorates respiratory distress syndrome-associated neonatal lethality in Erk3(-/-) mouse pups.Pediatric research · 2014Article
- Corticotropin-releasing factor secretion from dendritic cells stimulated by commensal bacteria.World journal of gastroenterology · 2011Article
- Corticotropin-releasing factor signaling and visceral response to stress.Experimental biology and medicine (Maywood, N.J.) · 2010Review
- Urocortin-like immunoreactivity in the primary lymphoid organs of the duck (European journal of histochemistry : EJH · 2009Article
- Neuropeptides as signal molecules in common with leukocytes and the hypothalamic-pituitary-adrenal axis.Brain, behavior, and immunity · 2008Article
- The regulation of neuroendocrine function: Timing is everything.Hormones and behavior · 2006Review
- The androgen 5alpha-dihydrotestosterone and its metabolite 5alpha-androstan-3beta, 17beta-diol inhibit the hypothalamo-pituitary-adrenal response to stress by acting through estrogen receptor beta-expressing neurons in the hypothalamus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Corticotropin-releasing hormone (CRH) requirement in Clostridium difficile toxin A-mediated intestinal inflammation.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Genetic animal models of anxiety.Neurogenetics · 2003Review
- Protection from pancreatitis by the zymogen granule membrane protein integral membrane-associated protein-1.The Journal of biological chemistry · 2002Article
- Mortality in 7B2 null mice can be rescued by adrenalectomy: involvement of dopamine in ACTH hypersecretion.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Decreased postnatal survival and altered body weight regulation in procolipase-deficient mice.The Journal of biological chemistry · 2002Article
- Interleukin-6 is an essential, corticotropin-releasing hormone-independent stimulator of the adrenal axis during immune system activation.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Altered stress-induced anxiety in adenylyl cyclase type VIII-deficient mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Circadian rise in maternal glucocorticoid prevents pulmonary dysplasia in fetal mice with adrenal insufficiency.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Corticotropin-releasing hormone (CRH), one of the primary regulators of the hypothalamic-pituitary-adrenal (HPA) axis, exhibits abnormal regulation in pathologic states such as depression and anorexia nervosa. Analysis of the role of CRH in regulation of the HPA axis would be facilitated by the creation of animal models in which CRH gene structure and function could be manipulated. We have determined the DNA sequence of the mouse CRH gene. Using a highly sensitive reverse transcription-polymerase chain reaction method, we have found expression of CRH mRNA in adrenal, ovary, testis, gut, heart, anterior pituitary, lung, and spleen, in addition to cerebral cortex and hypothalamus. Within the spleen, CRH mRNA is localized specifically to T-lymphocytes. We mapped the chromosomal location of mouse CRH via interspecific mouse backcrosses to chromosome 3, which is not the site of any naturally occurring mutations consistent with CRH deficiency. Because of this, we inactivated a CRH allele in mouse embryonic stem (ES) cells by homologous recombination with a mutant mouse CRH gene lacking the entire coding region of preproCRH. Mice chimeric for each of two ES clones with an inactivated CRH allele are being used to generate animals with complete CRH deficiency.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.