ArticleInfection
IL-6 and TNF alpha release in association with neutrophil activation after cardiopulmonary bypass surgery.
Article in Infection. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed, 31 citations in OpenAlex.
- The impact of two different transfusion strategies on patient immune response during major abdominal surgery: a preliminary report.Journal of immunology research · 2014Trial
- Comparison of the effects of desflurane and propofol anesthesia on the inflammatory response and s100β protein during coronary artery bypass grafting.Inflammation · 2013Trial
- Induction of acute-phase reactive substances during open-heart surgery and efficacy of ulinastatin. Inhibiting cytokines and postoperative organ injury.The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi · 2000Trial
- Endotoxemia related to cardiopulmonary bypass is associated with increased risk of infection after cardiac surgery: a prospective observational study.Critical care (London, England) · 2011Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The serum IL-6 and TNF alpha response to cardiopulmonary bypass surgery was studied in 12 patients. Human neutrophil elastase was also measured in order to detect the presence of neutrophil activation. Peripheral venous blood samples were obtained before, during, and 1, 2, 3 and 6 days after surgery. Intra-operative samples were also obtained from the coronary sinus and pulmonary artery. Cardiopulmonary bypass stimulated the immediate release of IL-6 into the coronary, pulmonary and systemic circulations. TNF alpha was transiently detected in the pulmonary circulation in seven patients. Surgery also induced early and sustained activation of neutrophils, which peaked 24 h following maximum IL-6 release. Both IL-6 and TNF alpha not only enhance neutrophil activation, but also stimulate an adhesive neutrophil-cardiac myocyte interaction which is associated with the release of toxic oxygen radicals. Their detection, in association with concomitant neutrophil activation, suggests a possible pathway for enhanced neutrophil mediated myocardial damage following cardiopulmonary bypass surgery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.