ReviewMolecular neurobiology
Structure, function and expression of voltage-dependent sodium channels.
Review in Molecular neurobiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 71 citations in OpenAlex.
- Role of ion channels in the mechanism of proteinuria (Review).Experimental and therapeutic medicine · 2023Review
- Substituted N-(biphenyl-4'-yl)methyl (R)-2-acetamido-3-methoxypropionamides: potent anticonvulsants that affect frequency (use) dependence and slow inactivation of sodium channels.Journal of medicinal chemistry · 2014Article
- More than a bystander: the contributions of intrinsic skeletal muscle defects in motor neuron diseases.Frontiers in physiology · 2013Review
- Early onset muscle weakness and disruption of muscle proteins in mouse models of spinal muscular atrophy.Skeletal muscle · 2013Article
- A selective role for MRF4 in innervated adult skeletal muscle: Na(V) 1.4 Na+ channel expression is reduced in MRF4-null mice.Gene expression · 2005Article
- Domain 2 of Drosophila para voltage-gated sodium channel confers insect properties to a rat brain channel.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Isoform-specific effects of sialic acid on voltage-dependent Na+ channel gating: functional sialic acids are localized to the S5-S6 loop of domain I.The Journal of physiology · 2002Article
- Channel cytoplasmic loops alter voltage-dependent sodium channel activation in an isoform-specific manner.The Journal of physiology · 2001Article
- Effects of channel cytoplasmic regions on the activation mechanisms of cardiac versus skeletal muscle Na(+) channels.Biophysical journal · 1999Article
- Tonic and phasic tetrodotoxin block of sodium channels with point mutations in the outer pore region.Biophysical journal · 1999Article
- Article
- Extrapore residues of the S5-S6 loop of domain 2 of the voltage-gated skeletal muscle sodium channel (rSkM1) contribute to the mu-conotoxin GIIIA binding site.Biophysical journal · 1998Article
- Glutamine substitution at alanine1649 in the S4-S5 cytoplasmic loop of domain 4 removes the voltage sensitivity of fast inactivation in the human heart sodium channel.The Journal of general physiology · 1998Article
- Isolation of a human-brain sodium-channel gene encoding two isoforms of the subtype III alpha-subunit.Journal of molecular neuroscience : MN · 1998Article
- Estrogen modifies an electrocommunication signal by altering the electrocyte sodium current in an electric fish, Sternopygus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Modulation of the human cardiac sodium channel alpha-subunit by cAMP-dependent protein kinase and the responsible sequence domain.The Journal of physiology · 1997Article
- Identification of mutations in the housefly para-type sodium channel gene associated with knockdown resistance (kdr) to pyrethroid insecticides.Molecular & general genetics : MGG · 1996Article
- Starburst amacrine cells change from spiking to nonspiking neurons during retinal development.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Structure and functional expression of a new member of the tetrodotoxin-sensitive voltage-activated sodium channel family from human neuroendocrine cells.The EMBO journal · 1995Article
- Basic helix-loop-helix factors recruit nuclear factor I to enhance expression of the NaV 1.4 Na+ channel gene.Biochimica et biophysica actaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Voltage-dependent sodium channels control the transient inward current responsible for the action potential in most excitable cells. Members of this multigene family have been cloned, sequenced, and functionally expressed from various tissues and species, and common features of their structure have clearly emerged. Site-directed mutagenesis coupled with in vitro expression has provided additional insight into the relationship between structure and function. Subtle differences between sodium channel isoforms are also important, and aspects of the regulation of sodium channel gene expression and the modulation of channel function are becoming topics of increasing importance. Finally, sodium channel mutations have been directly linked to human disease, yielding insight into both disease pathophysiology and normal channel function. After a brief discussion of previous work, this review will focus on recent advances in each of these areas.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.