ArticleAmerican journal of human genetics1994
Predisposition for breast cancer in carriers of constitutional translocation 11q;22q.
Article in American journal of human genetics, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 54 citations in OpenAlex.
- Emanuel Syndrome: A Case Report With Isolated Nuchal Translucency Thickening.Case reports in genetics · 2025Article
- Mortality and cancer incidence in carriers of constitutional t(11;22)(q23;q11) translocations: A prospective study.International journal of cancer · 2019Article
- The effect of translocation-induced nuclear reorganization on gene expression.Genome research · 2010Article
- Risk of breast cancer not increased in translocation 11;22 carriers: analysis of 80 pedigrees.American journal of medical genetics. Part A · 2010Article
- Hereditary breast and ovarian cancer.Hereditary cancer in clinical practice · 2008Article
- A unique case of der(11)t(11;22),-22 arising from 3:1 segregation of a maternal t(11;22) in a family with co-segregation of the translocation and breast cancer.Prenatal diagnosis · 2005Article
- Detailed deletion mapping at chromosome 11q23 in colorectal carcinoma.British journal of cancer · 2000Article
- Tightly clustered 11q23 and 22q11 breakpoints permit PCR-based detection of the recurrent constitutional t(11;22).American journal of human genetics · 2000Article
- European multicenter study on LOH of APOC3 at 11q23 in 766 breast cancer patients: relation to clinical variables. Breast Cancer Somatic Genetics Consortium.British journal of cancer · 1999Article
- Loss of heterozygosity at chromosome 11 in breast cancer: association of prognostic factors with genetic alterations.British journal of cancer · 1995Article
- Familial breast cancer and genes involved in breast carcinogenesis.Breast cancer research and treatment · 1995Review
- Intravascular Large B-cell Lymphoma of the Bilateral Ovaries and Uterus in an Asymptomatic Patient with a t(11;22)(q23;q11) Constitutional Translocation.Internal medicine (Tokyo, Japan)Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A translocation between the long arms of chromosomes 11 and 22, t(11;22)(q23;q11), is the most frequent constitutional reciprocal translocation in man. This chromosome abnormality has not previously been reported to be associated with an increased risk for neoplasia. The observation of one patient with a constitutional translocation t(11q;22q) and breast cancer prompted us to study the relationship between these two conditions. The incidence of breast cancer was determined in carriers of t(11q;22q). The karyotypes were determined by QFQ-banding, and the breakpoints were then further characterized by fluorescent in situ hybridization. Eight families with a total of 22 balanced carriers were found. In five of these families there was one case of breast cancer each. In another family a case of an unknown malignancy was reported in one member. No other malignancies were found among these patients. The number of breast cancer cases was significantly higher than expected among the translocation carriers (P < .001). The chromosomal breakpoints showed the same localization with the markers used, in the seven families studied. The association of constitutional translocation t(11q;22q) and breast cancer identifies a subset of patients with a highly increased risk for breast cancer who would benefit from counseling and screening. It also suggests the involvement of genes on 11q and/or 22q, in the tumorigenesis of breast cancer.
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8178827PMC1918254W1603626531What OpenQuestion holds
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