ArticleNucleic acids research1993
Kappa immunoglobulin promoters and enhancers display developmentally controlled interactions.
Article in Nucleic acids research, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 37 citations in OpenAlex.
- A new hypersensitive site, HS10, and the enhancers, E3' and Ed, differentially regulate Igκ gene expression.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Targeted overexpression of an activated N-ras gene results in B-cell and plasma cell lymphoproliferation and cooperates with c-myc to induce fatal B-cell neoplasia.Experimental hematology · 2012Article
- AID-dependent activation of a MYC transgene induces multiple myeloma in a conditional mouse model of post-germinal center malignancies.Cancer cell · 2008Article
- Immunoglobulin kappa enhancers are differentially regulated at the level of chromatin structure.Molecular immunology · 2007Article
- Novel targeted deregulation of c-Myc cooperates with Bcl-X(L) to cause plasma cell neoplasms in mice.The Journal of clinical investigation · 2004Article
- Regulation of V(D)J recombination by transcriptional promoters.Molecular and cellular biology · 1999Article
- Transcription factor Pip can enhance DNA binding by E47, leading to transcriptional synergy involving multiple protein domains.Molecular and cellular biology · 1998Article
- Coordinate transcription and V(D)J recombination of the kappa immunoglobulin light-chain locus: NF-kappaB-dependent and -independent pathways of activation.Molecular and cellular biology · 1997Article
- Octamer independent activation of transcription from the kappa immunoglobulin germline promoter.Nucleic acids research · 1996Article
- A potential role for Elf-1 in terminal transferase gene regulation.Molecular and cellular biology · 1996Article
- A developmentally modulated chromatin structure at the mouse immunoglobulin kappa 3' enhancer.Molecular and cellular biology · 1996Article
- A defective Vkappa A2 allele in Navajos which may play a role in increased susceptibility to haemophilus influenzae type b disease.The Journal of clinical investigation · 1996Article
- TATA box and Sp1 sites mediate the activation of c-myc promoter P1 by immunoglobulin kappa enhancers.Gene expression · 1996Article
- An AP1 binding site upstream of the kappa immunoglobulin intron enhancer binds inducible factors and contributes to expression.Nucleic acids research · 1994Article
- Selective synergy of immunoglobulin enhancer elements in B-cell development: a characteristic of kappa light chain enhancers, but not heavy chain enhancers.Nucleic acids research · 1994Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have investigated the interaction of the kappa immunoglobulin light chain intron and 3' enhancers with two different kappa promoters at distinct stages of B-cell development. We find that transiently transfected reporter gene constructs driven by either the kappa V-region promoter, or the kappa germline promoter, are controlled by the known enhancers of the locus in a developmentally regulated fashion. We have, however, observed differences in promoter activation by each enhancer. Moreover, constructs controlled by a combination of both enhancers are synergistically activated at the B-cell and plasma cell stages as compared with constructs containing either enhancer alone. This synergy is not observed early in development, at the pre-B cell stage. The pattern of enhancer and promoter interactions is discussed in the context of the known developmental regulation of the locus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.