ArticleMolecular & general genetics : MGG1994
The evolutionary origin of the 35 kb circular DNA of Plasmodium falciparum: new evidence supports a possible rhodophyte ancestry.
Article in Molecular & general genetics : MGG, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Divergent Plastid Genomes in the Deepest-Branching Apicomplexan Parasites.Genome biology and evolution · 2025Article
- Insights into the mitochondrial genome structure and phylogenetic placement of Theileria velifera in comparison to other apicomplexan parasites.Scientific reports · 2025Article
- New insights into apicoplast metabolism in blood-stage malaria parasites.Current opinion in microbiology · 2023Review
- Roles of the apicoplast across the life cycles of rodent and human malaria parasites.The Journal of eukaryotic microbiology · 2022Review
- Validation of Putative Apicoplast-Targeting Drugs Using a Chemical Supplementation Assay in Cultured Human Malaria Parasites.Antimicrobial agents and chemotherapy · 2018Article
- The apicoplast: now you see it, now you don't.International journal for parasitology · 2017Review
- Biology of the Marine Heterotrophic DinoflagellateMicroorganisms · 2013Review
- The search for the missing link: a relic plastid in Perkinsus?International journal for parasitology · 2011Review
- The apicoplast.Protoplasma · 2011Review
- What do human parasites do with a chloroplast anyway?PLoS biology · 2011Review
- Identification of potential apicoplast associated therapeutic targets in human and animal pathogen Toxoplasma gondii ME49.Bioinformation · 2011Article
- An update on the rapid advances in malaria parasite cell biology.Trends in parasitology · 2010Article
- The YlmG protein has a conserved function related to the distribution of nucleoids in chloroplasts and cyanobacteria.BMC plant biology · 2010Article
- The endosymbiotic origin, diversification and fate of plastids.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Review
- An apicomplexan ankyrin-repeat histone deacetylase with relatives in photosynthetic eukaryotes.International journal for parasitology · 2009Article
- Targeting the fatty acid biosynthesis enzyme, beta-ketoacyl-acyl carrier protein synthase III (PfKASIII), in the identification of novel antimalarial agents.Journal of medicinal chemistry · 2009Article
- From chloroplasts to "cryptic" plastids: evolution of plastid genomes in parasitic plants.Current genetics · 2008Review
- Type I and type II fatty acid biosynthesis in Eimeria tenella: enoyl reductase activity and structure.Parasitology · 2007Article
- Genome sequence of Babesia bovis and comparative analysis of apicomplexan hemoprotozoa.PLoS pathogens · 2007Article
- Tetracyclines specifically target the apicoplast of the malaria parasite Plasmodium falciparum.Antimicrobial agents and chemotherapy · 2006Article
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Authors and funding
6 authors.
Funding
Abstract
In common with other Apicomplexan parasites, Plasmodium falciparum carries two extrachromosomal DNAs, one of which, the 6 kb element, is undoubtedly mitochondrial. The second, generally referred to as the 35 kb circle, is of unknown provenance, but the nature and organization of its genetic content makes a mitochondrial association unlikely and the molecule has features reminiscent of plastid genomes. We now report the occurrence on the circle of an open reading frame specifying a predicted 470 amino acid protein that shares more than 50% identity with a gene currently known only on the plastome of red algae. This high degree of conservation confirms the 35 kb circle's plastid ancestry, and we speculate that it may have originated from the rhodoplast of an ancient red algal endosymbiont in the progenitor of the Apicomplexa.
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