ArticleThe Biochemical journal1994
Characterization and localization of a 77 kDa protein related to the dystrophin gene family.
Article in The Biochemical journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 55 citations in OpenAlex.
- Cardiac Cell Remodeling in Obesity and Diabetes.Handbook of experimental pharmacology · 2026Review
- The role of the dystrophin glycoprotein complex in muscle cell mechanotransduction.Communications biology · 2022Review
- Dystrophin Dp71 and the Neuropathophysiology of Duchenne Muscular Dystrophy.Molecular neurobiology · 2020Review
- Evidence of the involvement of dystrophin Dp71 in corneal angiogenesis.Molecular vision · 2019Article
- Cardiac T-Tubule Microanatomy and Function.Physiological reviews · 2017Review
- Novel Nuclear Protein Complexes of Dystrophin 71 Isoforms in Rat Cultured Hippocampal GABAergic and Glutamatergic Neurons.PloS one · 2015Article
- Article
- Dp71, utrophin and beta-dystroglycan expression and distribution in PC12/L6 cell cocultures.Neuroreport · 2007Article
- Dystrophin Dp71f associates with the beta1-integrin adhesion complex to modulate PC12 cell adhesion.Journal of molecular biology · 2006Article
- Dystrophin Dp71 in PC12 cell adhesion.Neuroreport · 2005Article
- Glutamate regulates dystrophin-71 levels in glia cells.Neurochemical research · 2005Article
- Formation of multiple complexes between beta-dystroglycan and dystrophin family products.Journal of muscle research and cell motility · 2003Article
- Dystrophin-associated proteins in obliquely striated muscle of the leech Pontobdella muricata (Annelida, Hirudinea).The Histochemical journal · 2001Article
- Dystrophin and utrophin complexed with different associated proteins in cardiac Purkinje fibres.The Histochemical journal · 1999Article
- Utrophin and dystrophin-associated glycoproteins in normal and dystrophin deficient cardiac muscle.Journal of muscle research and cell motility · 1999Article
- Re-evaluation of the distributions of dystrophin and utrophin in sciatic nerve.The Biochemical journal · 1995Article
- A mutation in the dystrophin gene selectively affecting dystrophin expression in the heart.The Journal of clinical investigation · 1995Article
- The dystrophin superfamily: variability and complexity.Journal of muscle research and cell motility · 1994Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Duchenne muscular dystrophy gene gives rise to transcripts of several lengths. These mRNAs differ in their coding content and tissue distribution. The 14 kb mRNA encodes dystrophin, a 427 kDa protein found in muscle and brain, and the short transcripts described encode DP71, a 77 kDa protein found in various organs. These short transcripts have many features common to the deduced primary structure of dystrophin, especially in the cysteine-rich specific C-terminal domains. The dystrophin C-terminal domain could be involved in membrane anchorage via the glycoprotein complex, but such a functional role for these short transcript products has yet to be demonstrated. Here we report the first isolation of a short transcript product from saponin-solubilized cardiac muscle membranes using alkaline buffer and affinity chromatography procedures. This molecule was found to be glycosylated and could be easily dissociated from cardiac muscle and other non-muscle tissues such as brain and liver. DP71-specific monoclonal antibody helped to identify this molecule as being related to the dystrophin gene family. Immunofluorescence analysis of bovine or chicken cardiac muscle showed a periodic distribution of DP71 in transverse T tubules and this protein was co-localized with the dystrophin glycoprotein complex in the Z-disk area.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.