ArticleProceedings of the National Academy of Sciences of the United States of America1994
Correction of the DNA repair defect in xeroderma pigmentosum group E by injection of a DNA damage-binding protein.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 122 citations in OpenAlex.
- Review
- Hepatitis B Virus and DNA Damage Response: Interactions and Consequences for the Infection.Viruses · 2017Review
- Article
- Damaged DNA binding protein 2 in reactive oxygen species (ROS) regulation and premature senescence.International journal of molecular sciences · 2012Review
- Electrophoretic mobility shift assays for protein-DNA complexes involved in DNA repair.Methods in molecular biology (Clifton, N.J.) · 2012Article
- Multiple skin cancers in adults with mutations in the XP-E (DDB2) DNA repair gene.The Journal of investigative dermatology · 2011Article
- DNA damage response.Cold Spring Harbor perspectives in biology · 2011Review
- DDB2 complex-mediated ubiquitylation around DNA damage is oppositely regulated by XPC and Ku and contributes to the recruitment of XPA.Molecular and cellular biology · 2010Article
- The xeroderma pigmentosum group E gene product DDB2 activates nucleotide excision repair by regulating the level of p21Waf1/Cip1.Molecular and cellular biology · 2008Article
- Ubiquitylation-independent degradation of Xeroderma pigmentosum group C protein is required for efficient nucleotide excision repair.Nucleic acids research · 2007Article
- DDB1 maintains genome integrity through regulation of Cdt1.Molecular and cellular biology · 2006Article
- Xeroderma pigmentosum complementation group E protein (XPE/DDB2): purification of various complexes of XPE and analyses of their damaged DNA binding and putative DNA repair properties.Molecular and cellular biology · 2005Article
- Basal transcriptional regulation of human damage-specific DNA-binding protein genes DDB1 and DDB2 by Sp1, E2F, N-myc and NF1 elements.Nucleic acids research · 2003Article
- Drosophila damage-specific DNA-binding protein 1 (D-DDB1) is controlled by the DRE/DREF system.Nucleic acids research · 2002Article
- Review
- Sequential binding of UV DNA damage binding factor and degradation of the p48 subunit as early events after UV irradiation.Nucleic acids research · 2002Article
- DDB2 induces nuclear accumulation of the hepatitis B virus X protein independently of binding to DDB1.Journal of virology · 2001Article
- Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo.Molecular and cellular biology · 2001Article
- The xeroderma pigmentosum group E gene product DDB2 is a specific target of cullin 4A in mammalian cells.Molecular and cellular biology · 2001Article
- UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation.The EMBO journal · 2001Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Cells from a subset of patients with the DNA-repair-defective disease xeroderma pigmentosum complementation group E (XP-E) are known to lack a DNA damage-binding (DDB) activity. Purified human DDB protein was injected into XP-E cells to test whether the DNA-repair defect in these cells is caused by a defect in DDB activity. Injected DDB protein stimulated DNA repair to normal levels in those strains that lack the DDB activity but did not stimulate repair in cells from other xeroderma pigmentosum groups or in XP-E cells that contain the activity. These results provide direct evidence that defective DDB activity causes the repair defect in a subset of XP-E patients, which in turn establishes a role for this activity in nucleotide-excision repair in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.