ArticleProceedings of the National Academy of Sciences of the United States of America1994
Diffusivity of myoglobin in intact skeletal muscle cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 105 citations in OpenAlex.
- A versatile delivery vehicle for cellular oxygen and fuels or metabolic sensor? A review and perspective on the functions of myoglobin.Physiological reviews · 2024Review
- Capillary-Mitochondrial Oxygen Transport in Muscle: Paradigm Shifts.Function (Oxford, England) · 2023Review
- Oxygen flux from capillary to mitochondria: integration of contemporary discoveries.European journal of applied physiology · 2022Review
- Energy metabolism design of the striated muscle cell.Physiological reviews · 2021Review
- Image-based modelling of skeletal muscle oxygenation.Journal of the Royal Society, Interface · 2017Review
- Retinal oxygen distribution and the role of neuroglobin.Journal of mathematical biology · 2016Article
- Diffusion coefficients of endogenous cytosolic proteins from rabbit skinned muscle fibers.Biophysical journal · 2014Article
- To breathe or not to breathe: the haematopoietic stem/progenitor cells dilemma.British journal of pharmacology · 2013Review
- Facilitated diffusion of myoglobin and creatine kinase and reaction-diffusion constraints of aerobic metabolism under steady-state conditions in skeletal muscle.Biotechnology and bioengineering · 2012Article
- Effects of fiber type and size on the heterogeneity of oxygen distribution in exercising skeletal muscle.PloS one · 2012Article
- Endogenous myoglobin in breast cancer is hypoxia-inducible by alternative transcription and functions to impair mitochondrial activity: a role in tumor suppression?The Journal of biological chemistry · 2011Article
- Molecules in motion: influences of diffusion on metabolic structure and function in skeletal muscle.The Journal of experimental biology · 2011Review
- Myoglobin's old and new clothes: from molecular structure to function in living cells.The Journal of experimental biology · 2010Review
- Endogenous myoglobin in human breast cancer is a hallmark of luminal cancer phenotype.British journal of cancer · 2010Article
- A computational model of oxygen delivery by hemoglobin-based oxygen carriers in three-dimensional microvascular networks.Journal of theoretical biology · 2007Article
- Anisotropy and temperature dependence of myoglobin translational diffusion in myocardium: implication for oxygen transport and cellular architecture.Biophysical journal · 2007Article
- Myoglobin translational diffusion in rat myocardium and its implication on intracellular oxygen transport.The Journal of physiology · 2007Article
- Virtual cooperativity in myoglobin oxygen saturation curve in skeletal muscle in vivo.Dynamic medicine : DM · 2006Article
- Radial and longitudinal diffusion of myoglobin in single living heart and skeletal muscle cells.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Modeling advection and diffusion of oxygen in complex vascular networks.Annals of biomedical engineering · 2001Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report a method that allows us to determine the diffusion coefficient of native myoglobin in intact and mechanically unaffected red muscle fibers. The method is based on an optical recording of intracellular diffusion of metmyoglobin, which is produced inside the cells by photooxidation of oxymyoglobin with a UV light pulse. We find a myoglobin diffusivity of 1.2 x 10(-7) cm2/s (22 degrees C), which is only 1/10th of the value measured in very dilute myoglobin solutions and 1/5th of the value obtained from measurements in solutions of myoglobin at 18 g/dl. The latter value often has been used in model calculations of oxygen transport to tissue incorporating myoglobin-facilitated oxygen diffusion. Recalculating facilitated diffusion with the value obtained by us implies that its contribution to total intracellular oxygen transport is of minor importance. Furthermore, it shows that sterical hindrance to myoglobin diffusion is dominated by the muscle-cell architecture rather than by the overall protein concentration of the muscle fiber.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.