ArticleProceedings of the National Academy of Sciences of the United States of America1994
Allelotyping of butadiene-induced lung and mammary adenocarcinomas of B6C3F1 mice: frequent losses of heterozygosity in regions homologous to human tumor-suppressor genes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 81 citations in OpenAlex.
- Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression.Carcinogenesis · 2015Review
- Frequent mutations of the Trp53, Hras1 and beta-catenin (Catnb) genes in 1,3-butadiene-induced mammary adenocarcinomas in B6C3F1 mice.Oncogene · 2002Article
- Review
- An AC-repeat adjacent to mouse Cdkn2B allows the detection of specific allelic losses in the p15INK4b and p16INK4a tumor suppressor genes.Mammalian genome : official journal of the International Mammalian Genome Society · 1998Article
- p53 gene mutation and loss of heterozygosity of chromosome 11 in methylcholanthrene-induced mouse sarcomas.Japanese journal of cancer research : Gann · 1998Article
- Mouse mammary tumor virus/v-Ha-ras transgene-induced mammary tumors exhibit strain-specific allelic loss on mouse chromosome 4.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Endogenous Mtv-encoded superantigens are not required for development of murine AIDS.Journal of virology · 1996Article
- An improved method for the isolation of type II and Clara cells from mice.In vitro cellular & developmental biology. Animal · 1995Article
- Genetic map of the region surrounding the retrovirus restriction locus, Fv1, on mouse chromosome 4.Mammalian genome : official journal of the International Mammalian Genome Society · 1995Article
- Assignment of a locus for mouse lung tumor susceptibility to proximal chromosome 19.Mammalian genome : official journal of the International Mammalian Genome Society · 1994Article
- Intracisternal A-type particle elements as genetic markers: detection by repeat element viral element amplified locus-PCR.Mammalian genome : official journal of the International Mammalian Genome Society · 1994Article
- Genome-wide search for loss of heterozygosity in transgenic mouse tumors reveals candidate tumor suppressor genes on chromosomes 9 and 16.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
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5 authors at 2 institutions in 1 country.
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Abstract
To identify the potential involvement of tumor-suppressor gene inactivation during neoplastic development in B6C3F1 mice, genetic losses were determined from allelotypes of butadiene-induced lung and mammary adenocarcinomas. By using length polymorphisms in restriction fragments and simple sequence repeats, or "microsatellites," markers on each autosome were analyzed for allele losses in tumor DNAs. Losses of heterozygosity on chromosome 11 were observed at several loci surrounding the p53 tumor-suppressor gene (Trp53) in 12 of 17 mammary tumors and 2 of 8 lung tumors. Although most of these alterations appeared to result from nondisjunction, at least two examples of somatic recombination or deletion were also observed. Southern analysis revealed a homozygous deletion of the remaining Trp53 allele of one of these mammary tumors. Losses of heterozygosity were also detected at the Rb-1 tumor-suppressor gene in 7 of 17 mammary tumors and 1 lung tumor. Finally, frequent allele losses were observed on chromosome 4 in lung tumors. Analysis of nine chromosome 4 loci defined an interstitial deletion containing the Ifa gene cluster in one of the lung tumors. A tumor-suppressor gene was previously mapped to this region of chromosome 4 in studies with somatic cell hybrids. In addition, homozygous deletions have been reported in a homologous region of human chromosome 9p for acute lymphocytic leukemias, glioblastomas, melanomas, and lung carcinomas. These findings suggest that the inactivation of tumor-suppressor genes including Trp53, Rb-1, and an unidentified gene on chromosome 4 plays a significant role during carcinogenesis in mice.
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