ArticleProceedings of the National Academy of Sciences of the United States of America1994
Selective 5-HT1D alpha serotonin receptor gene expression in trigeminal ganglia: implications for antimigraine drug development.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 124 citations in OpenAlex.
- Review
- Lasmiditan and 5-Hydroxytryptamine in the rat trigeminal system; expression, release and interactions with 5-HTThe journal of headache and pain · 2022Article
- Comprehensive RNA-Seq expression analysis of sensory ganglia with a focus on ion channels and GPCRs in Trigeminal ganglia.PloS one · 2013Article
- Serotonin and CGRP in migraine.Annals of neurosciences · 2012Review
- Review
- 5-HT(1F) Receptor agonists: a new treatment option for migraine attacks?Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2010Review
- Preclinical neuropharmacology of naratriptan.CNS drug reviews · 2005Review
- Involvement of 5-HT1B receptors in triptan-induced contractile responses in guinea-pig isolated iliac artery.Naunyn-Schmiedeberg's archives of pharmacology · 2004Article
- Review
- The anti-migraine 5-HT(1B/1D) agonist rizatriptan inhibits neurogenic dural vasodilation in anaesthetized guinea-pigs.British journal of pharmacology · 2001Article
- Pharmacokinetics and pharmacodynamics of the triptan antimigraine agents: a comparative review.Clinical pharmacokinetics · 2001Review
- No contractile effect for 5-HT1D and 5-HT1F receptor agonists in human and bovine cerebral arteries: similarity with human coronary artery.British journal of pharmacology · 2000Article
- Contractile 5-HT1B receptors in human cerebral arteries: pharmacological characterization and localization with immunocytochemistry.British journal of pharmacology · 1999Article
- Differential pharmacology between the guinea-pig and the gorilla 5-HT1D receptor as probed with isochromans (5-HT1D-selective ligands).British journal of pharmacology · 1999Article
- Repression of the calcitonin gene-related peptide promoter by 5-HT1 receptor activation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Thyroid parafollicular cells. An accessible model for the study of serotonergic neurons.Molecular neurobiology · 1996Review
- Promotion of cell growth by stimulation of cloned human 5-HT1D receptor sites in transfected C6-glial cells is highly sensitive to intrinsic activity at 5-HT1D receptors.Naunyn-Schmiedeberg's archives of pharmacology · 1996Article
- [Animal models and their results in relation to the therapy of migraine].Schmerz (Berlin, Germany) · 1996Article
- Blockade of porcine carotid vascular response to sumatriptan by GR 127935, a selective 5-HT1D receptor antagonist.British journal of pharmacology · 1996Article
- Pharmacology of cloned human 5-HT1D receptor-mediated functional responses in stably transfected rat C6-glial cell lines: further evidence differentiating human 5-HT1D and 5-HT1B receptors.Naunyn-Schmiedeberg's archives of pharmacology · 1996Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Pharmacological data suggest that the actions of antimigraine drugs such as sumatriptan may be mediated by 5-HT1D-like serotonin receptors on trigeminovascular nerve endings. We sought molecular evidence for the expression of an mRNA species encoding the 5-HT1D receptor subtype in guinea pig and human trigeminal ganglia, using the polymerase chain reaction with oligonucleotides uniquely homologous to the coding sequences of the 5-HT1B/D family (human 5-HT1D alpha and 5-HT1D beta; rat 5-HT1B). A single band of predicted size was observed in samples from guinea pig trigeminal ganglia; sequence analysis revealed the presence of a single message, which was 85% and 71% identical to the human 5-HT1D alpha and 5-HT1D beta receptor DNA sequences, respectively. Similar analyses of postmortem human trigeminal ganglia revealed the presence of 5-HT1D alpha, but not 5-HT1D beta, receptor message. Inasmuch as one recent report found that mRNA encoding only the 5-HT1D beta receptor subtype was expressed by vascular smooth muscle of the central nervous system, the present findings suggest the importance of developing selective 5-HT1D alpha receptor agonists as a strategy to reduce the risk of myocardial infarction and possibly stroke that complicates the acute treatment of migraine headache.
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