ArticleProceedings of the National Academy of Sciences of the United States of America1994
Id-1 as a possible transcriptional mediator of muscle disuse atrophy.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 55 citations in OpenAlex.
- Article
- Dnmt1 regulates the myogenic lineage specification of muscle stem cells.Scientific reports · 2016Article
- Physical and functional interaction between the ID1 and p65 for activation of NF-κB.American journal of physiology. Cell physiology · 2012Article
- Excitation-transcription coupling in skeletal muscle: the molecular pathways of exercise.Biological reviews of the Cambridge Philosophical Society · 2011Review
- Differential morphofunctional characteristics and gene expression in fast and slow muscle of rats with monocrotaline-induced heart failure.Journal of molecular histology · 2011Article
- Hypoxia inducible factor 1 links fast-patterned muscle activity and fast muscle phenotype in rats.The Journal of physiology · 2011Article
- Cellular and molecular events controlling skeletal muscle mass in response to altered use.Pflugers Archiv : European journal of physiology · 2008Review
- In vivo time-lapse microscopy reveals no loss of murine myonuclei during weeks of muscle atrophy.The Journal of clinical investigation · 2008Article
- Heart failure alters MyoD and MRF4 expressions in rat skeletal muscle.International journal of experimental pathology · 2006Article
- Myocyte enhancer factor 2 activates promoter sequences of the human AbetaH-J-J locus, encoding aspartyl-beta-hydroxylase, junctin, and junctate.Molecular and cellular biology · 2005Article
- Global analysis of gene expression patterns during disuse atrophy in rat skeletal muscle.The Journal of physiology · 2003Article
- The expression of the myogenic regulatory factors in denervated and normal muscles of different phenotypes.Journal of muscle research and cell motility · 2000Article
- Myogenin induces a shift of enzyme activity from glycolytic to oxidative metabolism in muscles of transgenic mice.The Journal of cell biology · 1999Article
- Overexpression of myogenin in muscles of transgenic mice: interaction with Id-1, negative crossregulation of myogenic factors, and induction of extrasynaptic acetylcholine receptor expression.Molecular and cellular biology · 1995Article
- Adaptation of nicotinic acetylcholine receptor, myogenin, and MRF4 gene expression to long-term muscle denervation.The Journal of cell biology · 1995Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Disuse of muscle leads to atrophy of the fibers. This atrophy is correlated with reduced transcription. We found that when muscle was denervated or paralyzed with a nerve impulse block, the mRNA for Id-1, a negative regulator of transcription, was increased 2- to 7-fold. To test the effect of high Id-1 levels in active muscles, we made transgenic mice in which Id-1 was overexpressed under control of regulatory elements which confer tissue- and fiber-type-specific expression in differentiated muscle cells. Fiber types with high transgene expression were atrophic compared to those in wild-type litter mates. In contrast, fiber types with low transgene expression displayed hypertrophy, presumably caused by an overload due to reduced strength in atrophic synergistic fibers. Apart from the selective effects on fiber caliber, the muscle tissue showed no signs of pathology, and apart from a characteristic slightly lower body weight, the transgenic animals looked and behaved normally. We suggest that in the mature muscle, Id-1 may be involved in regulating muscle fiber size at the transcriptional level during disuse.
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