Evidence map›Paper›PMID 8168976›Full record

ArticleInfection and immunity1994

Identification of two functional forms of immunoglobulin G3-binding protein expressed by group A streptococci.

T D Pack, R A Otten, R H Raeder, M D Boyle

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

T D PackDepartment of Microbiology, Medical College of Ohio, Toledo 43699.
R A Otten
R H Raeder
M D Boyle
University of Toledo Medical Center · US

Funding

HUMAN IGG SUBCLASS-SPECIFIC BACTERIAL BINDING PROTEINSR01AI030153 · NIAID · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI BOYLE, MICHAEL D. · 1993 to 1996
–
NIAID NIH HHS AI 30153
6 · The paper itself

Abstract

Analysis of group A streptococcal immunoglobulin G (IgG)-binding protein reactivity with different human IgG3-myeloma proteins provided evidence for at least two functional forms of these molecules. Representative IgG3-binding molecules were isolated, biotinylated, and used as tracers in competitive binding assays. Cross-inhibition studies demonstrated the existence of two distinct patterns of IgG3-binding activity. Proteins of one form could be inhibited from binding to an IgG3-myeloma protein by streptococcal protein G while binding of the second form was not inhibited. These studies further underscore the extent of heterogeneity among immunoglobulin-binding proteins expressed by group A streptococci.

Indexed as

AnimalsBacterial ProteinsHumansImmunoglobulin GMyeloma ProteinsReceptors, IgGStreptococcus pyogenesBacterial ProteinsIgG Fc-binding protein, StreptococcusImmunoglobulin GMyeloma ProteinsReceptors, IgG

Identifiers

PMID8168976
PMCPMC186474
OpenAlexW2132899100

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.