ArticleInfection and immunity1994
Antihistoplasma effect of activated mouse splenic macrophages involves production of reactive nitrogen intermediates.
Article in Infection and immunity, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 60 citations in OpenAlex.
- Nitric oxide for the prevention and treatment of viral, bacterial, protozoal and fungal infections.F1000Research · 2021Review
- Histoplasma Capsulatum: Mechanisms for Pathogenesis.Current topics in microbiology and immunology · 2019Review
- Histoplasma capsulatum surmounts obstacles to intracellular pathogenesis.The FEBS journal · 2016Review
- Protective Effect of Galectin-1 duringMediators of inflammation · 2016Article
- Histoplasma capsulatum, lung infection and immunity.Future microbiology · 2015Review
- Celecoxib improves host defense through prostaglandin inhibition during Histoplasma capsulatum infection.Mediators of inflammation · 2013Article
- Extracellular superoxide dismutase protects Histoplasma yeast cells from host-derived oxidative stress.PLoS pathogens · 2012Article
- A monoclonal antibody to Histoplasma capsulatum alters the intracellular fate of the fungus in murine macrophages.Eukaryotic cell · 2008Article
- Human dendritic cell activity against Histoplasma capsulatum is mediated via phagolysosomal fusion.Infection and immunity · 2005Article
- Age-related resistance of C57BL/6 mice to Cryptococcus neoformans is dependent on maturation of NKT cells.Infection and immunity · 2004Article
- Blockade of endogenous leukotrienes exacerbates pulmonary histoplasmosis.Infection and immunity · 2004Article
- Lack of nitric oxide synthase type 2 (NOS2) results in reduced neuronal apoptosis and mortality following mouse hepatitis virus infection of the central nervous system.Journal of neurovirology · 2002Article
- Host defence to pulmonary mycosis.The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses · 1999Article
- Effect of nitric oxide donors on survival of conidia, germination and growth of Aspergillus fumigatus in vitro.Folia microbiologica · 1995Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The mechanism by which recombinant murine gamma interferon (rMuIFN-gamma) and bacterial lipopolysaccharide (LPS) activate mouse resident splenic macrophages to inhibit the intracellular growth of the fungus Histoplasma capsulatum was examined. Growth inhibition depended on L-arginine metabolism. The growth inhibitory state normally induced by rMuIFN-gamma and LPS in resident splenic macrophages did not occur when the macrophages were cultured in the presence of NG-monomethyl-L-arginine, a competitive inhibitor of L-arginine metabolism. Resident splenic macrophages treated with rMuIFN-gamma and LPS produced nitrite (NO2-), an end product of L-arginine metabolism. When macrophages were cultured in the presence of NG-monomethyl-L-arginine together with rMuIFN-gamma and LPS, only baseline levels of NO2- were detected. Spleen cells from H. capsulatum-infected mice produced high levels of NO2- in culture. The production of NO2- correlated with in vitro inhibition of the intracellular growth of H. capsulatum. Anti-tumor necrosis factor alpha antibody did not block NO2- production by the immigrant splenic macrophages and did not abolish the antihistoplasma activity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.