ArticleInfection and immunity1994
Cloning and characterization of a potentially protective chitinase-like recombinant antigen from Wuchereria bancrofti.
Article in Infection and immunity, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 54 citations in OpenAlex.
- Susceptibility of Snails to Infection with Schistosomes is influenced by Temperature and Expression of Heat Shock Proteins.Epidemiology (Sunnyvale, Calif.) · 2015Article
- IgG subclass responses to proinflammatory fraction of Brugia malayi in human filariasis.The Indian journal of medical research · 2012Article
- Biomphalaria glabrata peroxiredoxin: effect of schistosoma mansoni infection on differential gene regulation.Molecular and biochemical parasitology · 2009Article
- Chitinase is stored and secreted from the inner body of microfilariae and has a role in exsheathment in the parasitic nematode Brugia malayi.Molecular and biochemical parasitology · 2008Article
- Essential role of chitinase in the development of the filarial nematode Acanthocheilonema viteae.Infection and immunity · 2008Article
- Brugia malayi adult low molecular weight IgG4-reactive antigens induce differential cytokine response in lymphocytes of endemic normal and asymptomatic microfilariae carriers in vitro.Journal of clinical immunology · 2007Article
- Host protective immunity and vaccine development studies in lymphatic filariasis.Indian journal of clinical biochemistry : IJCB · 2000Article
- The novel cuticular collagen Ovcol-1 of Onchocerca volvulus is preferentially recognized by immunoglobulin G3 from putatively immune individuals.Infection and immunity · 1997Article
- A family of lysozyme-like virulence factors in bacterial pathogens of plants and animals.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- A novel 95-kilodalton antigen of Wuchereria bancrofti infective larvae identified by species-specific monoclonal antibodies.Infection and immunity · 1996Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While there is no direct evidence demonstrating the existence of protective immunity to Wuchereria bancrofti infection in humans, the presence of individuals, in populations in areas where infection is endemic, with no clinical evidence of past or current infection despite appreciable exposure to the infective larvae, suggests that protective immunity to filarial parasites may occur naturally. Earlier work indicated that such putatively immune individuals generated antibodies to a 43-kDa antigen from larval extracts of the related filarial parasite Brugia malayi that was recognized by only 8% of the infected population. With rabbit antiserum raised against this 43-kDa antigen, this current study identified a recombinant clone, WbN43, with an insert size of 2.3 kb, from a W. bancrofti genomic expression library. The recombinant fusion protein was differentially recognized by the putatively immune individuals but not by the infected patients. The coding sequence (684 bp) from the 5' end had significant sequence similarity to chitinases from Serratia marcescens, Bacillus circulans, Streptomyces plicatus, and B. malayi. Peptide sequencing of the expressed product also defined a chitinase-like sequence. Molecular characterization indicated WbN43 to be a low-copy-number gene, with expression predominantly in infective larvae and microfilariae but not in adult parasites.
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