ArticleInfection and immunity1994
Systemic and mucosal immune responses in mice orally immunized with avirulent Salmonella typhimurium expressing a cloned Porphyromonas gingivalis hemagglutinin.
Article in Infection and immunity, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 44 citations in OpenAlex.
- Mucosal Vaccination Against Periodontal Disease: Current Status and Opportunities.Frontiers in immunology · 2021Review
- The Cytolethal Distending Toxin Contributes to Microbial Virulence and Disease Pathogenesis by Acting As a Tri-Perditious Toxin.Frontiers in cellular and infection microbiology · 2016Review
- TLR4 signaling via MyD88 and TRIF differentially shape the CD4+ T cell response to Porphyromonas gingivalis hemagglutinin B.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Salmonella vaccine vectors displaying delayed antigen synthesis in vivo to enhance immunogenicity.Infection and immunity · 2010Article
- Requirement of TLR4 and CD14 in dendritic cell activation by Hemagglutinin B from Porphyromonas gingivalis.Molecular immunology · 2009Article
- Effect of expression level on immune responses to recombinant oral Salmonella enterica serovar Typhimurium vaccines.Vaccine · 2009Article
- Gene therapy and its implications in Periodontics.Journal of Indian Society of Periodontology · 2009Article
- Hemagglutinin B is involved in the adherence of Porphyromonas gingivalis to human coronary artery endothelial cells.Infection and immunity · 2005Article
- Role of B7 costimulatory molecules in immune responses and T-helper cell differentiation in response to recombinant HagB from Porphyromonas gingivalis.Infection and immunity · 2004Article
- Immunization with Porphyromonas gingivalis capsular polysaccharide prevents P. gingivalis-elicited oral bone loss in a murine model.Infection and immunity · 2003Article
- Prevention of Porphyromonas gingivalis-induced oral bone loss following immunization with gingipain R1.Infection and immunity · 2001Article
- Long-term immunological memory induced by recombinant oral Salmonella vaccine vectors.Infection and immunity · 2000Article
- Effect of preexisting immunity to Salmonella on the immune response to recombinant Salmonella enterica serovar typhimurium expressing a Porphyromonas gingivalis hemagglutinin.Infection and immunity · 2000Article
- Expression and immunogenicity of hemagglutinin A from Porphyromonas gingivalis in an avirulent Salmonella enterica serovar typhimurium vaccine strain.Infection and immunity · 2000Article
- Host responses to recombinant hemagglutinin B of Porphyromonas gingivalis in an experimental rat model.Infection and immunity · 1999Article
- Immunogenicity of a Salmonella typhimurium aroA aroD vaccine expressing a nontoxic domain of Clostridium difficile toxin A.Infection and immunity · 1999Article
- The number of direct repeats in hagA is variable among Porphyromonas gingivalis strains.Infection and immunity · 1998Article
- Oral microbial ecology and the role of salivary immunoglobulin A.Microbiology and molecular biology reviews : MMBR · 1998Review
- Immunization of HLA-B27 transgenic and non transgenic mice with Salmonella typhimurium results predominantly in the generation of proliferative T cell responses.Clinical rheumatology · 1996Article
- A recombinant Salmonella typhimurium vaccine induces local immunity by four different routes of immunization.Infection and immunity · 1995Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Porphyromonas gingivalis produces a variety of virulence factors that may have a function in the periodontal disease process. Determination of the role of these various factors in pathogenesis and identification of a means for protecting the host from the destructive effects of this organism are areas of vigorous investigation. In this study we demonstrate the potential of avirulent Salmonella typhimurium strains to stimulate a specific systemic and mucosal immune response to a cloned P. gingivalis hemagglutinin (HagB). An avirulent strain of S. typhimurium, chi 4072, expressing the hagB gene of P. gingivalis 381 on the plasmid pDMD1 was intragastrically administered to BALB/c mice. These mice mounted a serum immunoglobulin G (IgG) and IgA primary response against the hagB gene product and a mucosal immune response as measured by evaluation of saliva. IgA antibodies were also detected in bile. These results demonstrate the feasibility of using attenuated S. typhimurium strains as carriers of P. gingivalis virulence factors for subsequent evaluation of the systemic and mucosal immune response against these antigens. This system will provide a means for evaluating the virulence factors of P. gingivalis for their suitability in the construction of potential vaccines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.