ArticleHuman genetics1994
Ancestry of SINE-R.C2 a human-specific retroposon.
Article in Human genetics, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 35 citations in OpenAlex.
- Structure and Expression Analyses of SVA Elements in Relation to Functional Genes.Genomics & informatics · 2013Article
- Allelic variation of HERV-K(HML-2) endogenous retroviral elements in human populations.Journal of molecular evolution · 2004Article
- SVA elements are nonautonomous retrotransposons that cause disease in humans.American journal of human genetics · 2003Article
- The viruses in all of us: characteristics and biological significance of human endogenous retrovirus sequences.Proceedings of the National Academy of Sciences of the United States of America · 1996Review
- Distribution of human endogenous retrovirus HERV-K genomes in humans and different primates.Human genetics · 1995Article
- Complement component C4 gene intron 9 as a phylogenetic marker for primates: long terminal repeats of the endogenous retrovirus ERV-K(C4) are a molecular clock of evolution.Immunogenetics · 1995Article
- Identification of a novel family of human endogenous retroviruses and characterization of one family member, HERV-K(C4), located in the complement C4 gene cluster.Nucleic acids research · 1994Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We have reported previously that a retroposon, containing a variable number of tandemly repeated nucleotide sequences, is present in the third intron of the human C2 gene. This element, termed SINE-R.C2, is a member of a large retroposon family derived from the endogenous retrovirus HERV-K10 and estimated to include a few thousand copies per haploid human genome. In the present study we analyzed genomic DNA from 175 humans from several ethnic groups including Americans of European and African descent, Chinese, Africans, Australians, Pacific Islanders, Japanese, and Koreans. They all contained SINE-R.C2, as indicated by Southern blotting. However, SINE-R.C2 was absent from the genome of nonhuman primates, although SINE-R-type elements were present in chimpanzees and gorillas and the HERV-K10 genome was apparently present in all primates except for New World monkeys. These results indicate that HERV-K10 was inserted into the genome after the divergence of New World monkeys; the prototype SINE-R element, after divergence of orangutans; and SINE-R.C2, after the split between humans and chimpanzees.
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