ArticleThe EMBO journal1994
Analysis of Ig-alpha-tyrosine kinase interaction reveals two levels of binding specificity and tyrosine phosphorylated Ig-alpha stimulation of Fyn activity.
Article in The EMBO journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 133 citations in OpenAlex.
- Repurposing dasatinib for diffuse large B cell lymphoma.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway.Science signaling · 2015Article
- Critical Role for an acidic amino acid region in platelet signaling by the HemITAM (hemi-immunoreceptor tyrosine-based activation motif) containing receptor CLEC-2 (C-type lectin receptor-2).The Journal of biological chemistry · 2013Article
- Activation of the B cell receptor leads to increased membrane proximity of the Igα cytoplasmic domain.PloS one · 2013Article
- Cis and trans regulatory mechanisms control AP2-mediated B cell receptor endocytosis via select tyrosine-based motifs.PloS one · 2013Article
- A computational model for early events in B cell antigen receptor signaling: analysis of the roles of Lyn and Fyn.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Fyn binds to and phosphorylates T cell immunoglobulin and mucin domain-1 (Tim-1).Molecular immunology · 2011Article
- Syk and pTyr'd: Signaling through the B cell antigen receptor.Biochimica et biophysica acta · 2009Review
- Epstein-barr virus latent membrane protein 2B (LMP2B) modulates LMP2A activity.Journal of virology · 2007Article
- B cell antigen receptor signaling and internalization are mutually exclusive events.PLoS biology · 2006Article
- Ligand-independent signaling during early avian B cell development.Immunologic research · 2006Review
- Src-family kinases in B-cell development and signaling.Oncogene · 2004Review
- A B cell receptor with two Igalpha cytoplasmic domains supports development of mature but anergic B cells.The Journal of experimental medicine · 2004Article
- Selection of B lymphocytes in the periphery is determined by the functional capacity of the B cell antigen receptor.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- B-cell antigen-receptor signalling in lymphocyte development.Immunology · 2003Review
- Positive and negative selection during B lymphocyte development.Immunologic research · 2003Review
- The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways.Molecular and cellular biology · 2002Article
- Ligand-independent signaling functions for the B lymphocyte antigen receptor and their role in positive selection during B lymphopoiesis.The Journal of experimental medicine · 2001Article
- Interference with immunoglobulin (Ig)alpha immunoreceptor tyrosine-based activation motif (ITAM) phosphorylation modulates or blocks B cell development, depending on the availability of an Igbeta cytoplasmic tail.The Journal of experimental medicine · 2001Article
- B cell development is arrested at the immature B cell stage in mice carrying a mutation in the cytoplasmic domain of immunoglobulin beta.The Journal of experimental medicine · 2001Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The B cell antigen receptor complex (BCR) is composed of membrane Ig and heterodimers of Ig-alpha and Ig-beta/gamma. Recent findings indicate that Ig-alpha associates with Src-family kinases, including Fyn and Lyn, via an approximately 26 amino acid motif termed ARH1. Studies reported here (i) define two mechanisms whereby this motif binds Fyn and (ii) reveal an important functional consequence of binding, i.e. kinase activation. Mutational analysis indicates that specific low-affinity binding is determined by a short sequence, -DCSM-, in the motif and is not dependent on motif tyrosine residues. In contrast, the doubly tyrosine phosphorylated motif binds independently of DCSM and with high affinity. Importantly, this binding leads to Fyn activation. Taken together with studies which map low-affinity binding of Fyn or Lyn to the kinase's N-terminal unique region and high-affinity binding to the kinase's SH2 domain, these results suggest a mechanism of BCR activation in which the non-phosphorylated resting receptor is associated with Src-family kinases and, upon stimulation, tyrosine phosphorylation of Ig-alpha leads to reorientation and activation of receptor-associated kinases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.