ArticleMolecular and cellular biology1994
The recombination signal sequence-binding protein RBP-2N functions as a transcriptional repressor.
Article in Molecular and cellular biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
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Who cites it
70 citing papers in PubMed, 167 citations in OpenAlex.
- Rbpj direct regulation of Atoh7 transcription in the embryonic mouse retina.Scientific reports · 2018Article
- Heterodimerization of AML1/ETO with CBFβ is required for leukemogenesis but not for myeloproliferation.Leukemia · 2017Article
- Notch1 maintains dormancy of olfactory horizontal basal cells, a reserve neural stem cell.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Mini-review: Does Notch promote or suppress cancer? New findings and old controversies.American journal of clinical and experimental urology · 2015Review
- Article
- Notch3 and Mef2c proteins are mutually antagonistic via Mkp1 protein and miR-1/206 microRNAs in differentiating myoblasts.The Journal of biological chemistry · 2012Article
- Non-canonical Notch signaling: emerging role and mechanism.Trends in cell biology · 2012Review
- Insensitive is a corepressor for Suppressor of Hairless and regulates Notch signalling during neural development.The EMBO journal · 2011Article
- Novel RBPJ transcripts identified in human amniotic fluid cells.Stem cell reviews and reports · 2010Article
- Notch and MAML-1 complexation do not detectably alter the DNA binding specificity of the transcription factor CSL.PloS one · 2010Article
- Wide-scale use of Notch signaling factor CSL/RBP-Jkappa in RTA-mediated activation of Kaposi's sarcoma-associated herpesvirus lytic genes.Journal of virology · 2010Article
- It's T-ALL about Notch.Oncogene · 2008Review
- A novel RBP-J kappa-dependent switch from C/EBP beta to C/EBP zeta at the C/EBP binding site on the C-reactive protein promoter.Journal of immunology (Baltimore, Md. : 1950) · 2007Article
- Kaposi's Sarcoma-associated herpesvirus lytic switch protein stimulates DNA binding of RBP-Jk/CSL to activate the Notch pathway.Journal of virology · 2006Article
- Viral DNA synthesis-dependent titration of a cellular repressor activates transcription of the human adenovirus type 2 IVa2 gene.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- EosFP, a fluorescent marker protein with UV-inducible green-to-red fluorescence conversion.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- RBP-J (CSL) is essential for activation of the K14/vGPCR promoter of Kaposi's sarcoma-associated herpesvirus by the lytic switch protein RTA.Journal of virology · 2004Article
- Dynamics of a human interparalog gene conversion hotspot.Genome research · 2004Article
- Expression of Notch-1 and its ligand Jagged-1 in rat liver during liver regeneration.Hepatology (Baltimore, Md.) · 2004Article
- RING1 inhibits transactivation of RBP-J by Notch through interaction with LIM protein KyoT2.Nucleic acids research · 2004Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have identified a cellular protein, RBP-2N, a presumed recombinase, as a repressor of transcription. Inhibition of transcription by RBP-2N was dependent on its DNA recognition site and was demonstrated in vitro and in vivo. This repression appears to be general, as transcription mediated by SP1 and Gal4/VP16 was inhibited by RBP-2N. The protein was purified to near homogeneity from human cells on the basis of its binding to a site present in the promoter of the adenovirus pIX gene. The DNA recognition sequence is 5'-TGGGAAAGAA, which is markedly different from the recombination signal sequence originally identified as the target site for this protein. The sequence of the purified protein is 97% identical with that published for the mouse RBP-2N protein. The reported homolog in Drosophila is Suppressor of Hairless. RBP-2N binding sites are present in a number of cellular and viral promoters, so RBP-2N may have a general role in transcriptional repression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.