ArticleMolecular and cellular biology1994
PEBP2 alpha B/mouse AML1 consists of multiple isoforms that possess differential transactivation potentials.
Article in Molecular and cellular biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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Who cites it
72 citing papers in PubMed, 199 citations in OpenAlex.
- The poly(C)-binding protein Pcbp2 is essential for CD4iScience · 2023Article
- Two Novel C-Terminus RUNX2 Mutations in Two Cleidocranial Dysplasia (CCD) Patients Impairing p53 Expression.International journal of molecular sciences · 2021Article
- Transcriptional Programming in Arteriosclerotic Disease: A Multifaceted Function of the Runx2 (Runt-Related Transcription Factor 2).Arteriosclerosis, thrombosis, and vascular biology · 2021Review
- Post-Translational Regulations of Transcriptional Activity of RUNX2.Molecules and cells · 2020Review
- Poly(C)-Binding Protein Pcbp2 Enables Differentiation of Definitive Erythropoiesis by Directing Functional Splicing of the Runx1 Transcript.Molecular and cellular biology · 2018Article
- Core Binding Factor β Expression in Ovarian Granulosa Cells Is Essential for Female Fertility.Endocrinology · 2018Article
- RUNX1: A Regulator of NF-kB Signaling in Pulmonary Diseases.Current protein & peptide science · 2018Review
- Mutant Runx2 regulates amelogenesis and osteogenesis through a miR-185-5p-Dlx2 axis.Cell death & disease · 2017Article
- Core Binding Factor-β Knockdown Alters Ovarian Gene Expression and Function in the Mouse.Molecular endocrinology (Baltimore, Md.) · 2016Article
- Loss of Runx2 in committed osteoblasts impairs postnatal skeletogenesis.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2015Article
- Runx1 exon 6-related alternative splicing isoforms differentially regulate hematopoiesis in mice.Blood · 2014Article
- Runx transcription factors repress human and murine c-Myc expression in a DNA-binding and C-terminally dependent manner.PloS one · 2013Article
- DNA methylation of RUNX3 in papillary thyroid cancer.The Korean journal of internal medicine · 2012Article
- Positional differences of axon growth rates between sensory neurons encoded by Runx3.The EMBO journal · 2012Article
- RUNX1 mutations in clonal myeloid disorders: from conventional cytogenetics to next generation sequencing, a story 40 years in the making.Critical reviews in oncogenesis · 2011Review
- Runx2 trans-activation mediated by the MSX2-interacting nuclear target requires homeodomain interacting protein kinase-3.Molecular endocrinology (Baltimore, Md.) · 2010Article
- The cleidocranial dysplasia-related R131G mutation in the Runt-related transcription factor RUNX2 disrupts binding to DNA but not CBF-beta.Journal of cellular biochemistry · 2010Article
- Developmentally regulated promoter-switch transcriptionally controls Runx1 function during embryonic hematopoiesis.BMC developmental biology · 2007Article
- Isoform-specific potentiation of stem and progenitor cell engraftment by AML1/RUNX1.PLoS medicine · 2007Article
- Regulation of the human LAT gene by the Elf-1 transcription factor.BMC molecular biology · 2006Article
12 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
A murine transcription factor, PEBP2, is composed of two subunits, alpha and beta. There are two genes in the mouse genome, PEBP2 alpha A and PEBP2 alpha B, which encode the alpha subunit. Two types of the alpha B cDNA clones, alpha B1 and alpha B2, were isolated from mouse fibroblasts and characterized. They were found to represent 3.8- and 7.9-kb transcripts, respectively. The 3.8-kb RNA encodes the previously described alpha B protein referred to as alpha B1, while the 7.9-kb RNA encodes a 387-amino-acid protein, termed alpha B2, which is identical to alpha B1 except that it has an internal deletion of 64 amino acid residues. Both alpha B1 and alpha B2 associate with PEBP2 beta and form a heterodimer. The alpha B2/beta complex binds to the PEBP2 binding site two- to threefold more strongly than the alpha B1/beta complex does. alpha B1 stimulates transcription through the PEBP2 site about 40-fold, while alpha B2 is only about 25 to 45% as active as alpha B1. Transactivation domain is located downstream of the 128-amino-acid runt homology region, referred to as the Runt domain. Mouse chromosome mapping studies revealed that alpha A, alpha B, and beta genes are mapped to chromosomes 17, 16, and 8, respectively. The last two genes are syntenic with the human AML1 on chromosome 21q22 and PEBP2 beta/CBF beta on 16q22 detected at the breakpoints of characteristic chromosome translocations of the two different subtypes of acute myeloid leukemia. These results suggest that previously described chimeric gene products, AML1/MTG8(ETO) and AML1-EAP generated by t(8;21) and t(3;21), respectively, lack the transactivation domain of AML1.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.