ArticleMolecular and cellular biology1994
Internally located and oppositely oriented polymerase II promoters direct convergent transcription of a LINE-like retroelement, the Dictyostelium repetitive element, from Dictyostelium discoideum.
Article in Molecular and cellular biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed.
- Retrotransposon targeting to RNA polymerase III-transcribed genes.Mobile DNA · 2018Review
- Retrotransposon Domestication and Control inFrontiers in microbiology · 2017Review
- Article
- A host factor supports retrotransposition of the TRE5-A population in Dictyostelium cells by suppressing an Argonaute protein.Mobile DNA · 2015Article
- Conserved gene regulatory function of the carboxy-terminal domain of dictyostelid C-module-binding factor.Eukaryotic cell · 2013Article
- Genetically tagged TRE5-A retrotransposons reveal high amplification rates and authentic target site preference in the Dictyostelium discoideum genome.Nucleic acids research · 2011Article
- The C-module-binding factor supports amplification of TRE5-A retrotransposons in the Dictyostelium discoideum genome.Eukaryotic cell · 2011Article
- Non-long terminal repeat (non-LTR) retrotransposons: mechanisms, recent developments, and unanswered questions.Mobile DNA · 2010Article
- rasiRNA pathway controls antisense expression of Drosophila telomeric retrotransposons in the nucleus.Nucleic acids research · 2009Article
- Role of RNA polymerase III transcription factors in the selection of integration sites by the dictyostelium non-long terminal repeat retrotransposon TRE5-A.Molecular and cellular biology · 2006Article
- The C-module DNA-binding factor mediates expression of the dictyostelium aggregation-specific adenylyl cyclase ACA.Eukaryotic cell · 2006Article
- Identification of multiple transcription initiation, polyadenylation, and splice sites in the Drosophila melanogaster TART family of telomeric retrotransposons.Nucleic acids research · 2006Article
- HeT-A and TART, two Drosophila retrotransposons with a bona fide role in chromosome structure for more than 60 million years.Cytogenetic and genome research · 2005Article
- Transposon telomeres are widely distributed in the Drosophila genus: TART elements in the virilis group.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Article
- The two Drosophila telomeric transposable elements have very different patterns of transcription.Molecular and cellular biology · 1999Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Dictyostelium discoideum NC4 genome harbors approximately 150 individual copies of a retrotransposable element called the Dictyostelium repetitive element (DRE). This element contains nonidentical terminal repeats (TRs) consisting of conserved building blocks A and B in the left TR and B and C in the right TR. Seven different-sized classes of RNA transcripts from these elements were resolved by Northern (RNA) blot analysis, but their combined abundance was very low. When D. discoideum cells were grown in the presence of the respiratory chain blocker antimycin A, steady-state concentrations of these RNA species increased 10- to 20-fold. The D. discoideum genome contains two DRE subtypes, the full-length 5.7-kb DREa and the internally deleted 2.4-kb DREb. Both subtypes are transcribed, as confirmed by analysis of cloned cDNA. Primary transcripts from the sense strand originate at nucleotide +1 and terminate at two dominant sites, located 21 or 28 nucleotides upstream from the 3' end of the elements. The activity of a reasonably strong polymerase II promoter in the 5'-terminal A module is slightly upregulated by the tRNA gene located 50 +/- 4 nucleotides upstream and drastically reduced by the adjacent B module of the DRE. Transcripts from the opposite DNA strand (complementary-sense transcripts) were also detected, directed by an internally located polymerase II promoter residing within the C module. This latter transcription was initiated at multiple sites within the oligo(dA12) stretch which terminates DREs.
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