ArticleThe Journal of cell biology1994
Expression of NCAM containing VASE in neurons can account for a developmental loss in their neurite outgrowth response to NCAM in a cellular substratum.
Article in The Journal of cell biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 62 citations in OpenAlex.
- Integration of multi-omics data reveals a novel hybrid breast cancer subtype and its biomarkers.Frontiers in oncology · 2023Article
- Cell Proliferation and Collective Cell Migration During Zebrafish Lateral Line System Development Are Regulated by Ncam/Fgf-Receptor Interactions.Frontiers in cell and developmental biology · 2020Article
- A holistic approach to dissecting SPARC family protein complexity reveals FSTL-1 as an inhibitor of pancreatic cancer cell growth.Scientific reports · 2016Article
- PQBP1, a factor linked to intellectual disability, affects alternative splicing associated with neurite outgrowth.Genes & development · 2013Article
- The heparan sulfate co-receptor and the concentration of fibroblast growth factor-2 independently elicit different signalling patterns from the fibroblast growth factor receptor.Cell communication and signaling : CCS · 2010Article
- Neuritogenic and neuroprotective properties of peptide agonists of the fibroblast growth factor receptor.International journal of molecular sciences · 2010Review
- Role of glial cell line-derived neurotrophic factor (GDNF)-neural cell adhesion molecule (NCAM) interactions in induction of neurite outgrowth and identification of a binding site for NCAM in the heel region of GDNF.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Breast cancer progression: controversies and consensus in the molecular mechanisms of metastasis and EMT.Journal of mammary gland biology and neoplasia · 2007Article
- Effects of nicotine on neurogenesis and plasticity of hippocampal neurons.Journal of neural transmission (Vienna, Austria : 1996) · 2005Article
- A synthetic neural cell adhesion molecule mimetic peptide promotes synaptogenesis, enhances presynaptic function, and facilitates memory consolidation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Atomic force microscopy captures length phenotypes in single proteins.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- The role of glycoproteins in neural development function, and disease.Molecular neurobiology · 1998Review
- Neural cell adhesion molecule (NCAM) as a quantitative marker in synaptic remodeling.Neurochemical research · 1995Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Binding of the neural cell adhesion molecule (NCAM) in neurons to NCAM on non-neuronal cells can stimulate axonal growth. A developmentally regulated loss of this response is associated with the insertion of 10 amino acids (called VASE) into the fourth Ig domain in up to 50% of the NCAM receptors in neurons. In the present study we have transfected PC12 cells with the major neuronal isoforms of human NCAM and tested cells expressing these isoforms for their ability to respond to NCAM in a cellular substratum. Whereas both the 140- and 180-kD isoforms of NCAM can act as functional receptors for neurite outgrowth, the presence of the VASE sequence in a minority of the receptors specifically inhibited this response. A synthetic peptide containing the VASE sequence inhibits neurite outgrowth from PC12 cells and primary neurons stimulated by NCAM. The same peptide has no effect on integrin dependent neurite outgrowth or neurite outgrowth stimulated by N-cadherin or L1. We discuss the possibility that the VASE peptide inhibits the NCAM response by preventing NCAM from binding to the FGF receptor in the plasma membrane.
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