ArticleDiabetologia1994
Thinness at birth and insulin resistance in adult life.
Article in Diabetologia, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 143 papers, 3 of them syntheses that pooled it.
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Who cites it
143 citing papers in PubMed, 3 syntheses or guidelines pooled it, 706 citations in OpenAlex.
- Hemodynamic changes in pregnancies with impaired fetal growth: A systematic review and meta-analysis.Acta obstetricia et gynecologica Scandinavica · 2026Pooled it
- Systematic review and meta-analysis on the relationship between prenatal stress and metabolic syndrome intermediate phenotypes.International journal of obesity (2005) · 2020Pooled it
- What is the relationship between exercise and metabolic abnormalities? A review of the metabolic syndrome.Sports medicine (Auckland, N.Z.) · 2004Pooled it
- Undernutrition-related diabetes in mice is linked to early undernutrition.American journal of physiology. Endocrinology and metabolism · 2026Article
- Maternal dietary citrulline supplementation increases fetal growth and programs pancreatic development in the lambs.Amino acids · 2026Article
- Placental gene signatures associated with high neonatal adiposity: role for immune cell activation.Journal of the Endocrine Society · 2026Article
- Statin therapy on dementia in elderly type 2 diabetes patients with delirium.Diabetology & metabolic syndrome · 2025Article
- The impact of short maternal height on gestational diabetes.Acta diabetologica · 2025Article
- The fascinating theory of fetal programming of adult diseases: A review of the fundamentals of the Barker hypothesis.Journal of public health research · 2024Article
- Blood-Biomarkers for Glucose Metabolism in Preterm Infants.Biomedicines · 2023Article
- Long-term outcomes of statin dose, class, and use intensity on primary prevention of cardiovascular mortality: a national T2DM cohort study.European journal of clinical pharmacology · 2023Article
- Optimal statin use for prevention of sepsis in type 2 diabetes mellitus.Diabetology & metabolic syndrome · 2023Article
- Effects of Statin Dose, Class, and Use Intensity on All-Cause Mortality in Patients with Type 2 Diabetes Mellitus.Pharmaceuticals (Basel, Switzerland) · 2023Article
- H1-antihistamine use and head and neck cancer risk in type 2 diabetes mellitus.Oncology research · 2023Article
- Nutritional Programming: History, Hypotheses, and the Role of Prenatal Factors in the Prevention of Metabolic Diseases-A Narrative Review.Nutrients · 2022Review
- Early life programming of health and disease: The long-term consequences of obesity in pregnancy.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2022Review
- Article
- Therapeutic advances in overcoming intrauterine growth restriction induced metabolic syndrome.Frontiers in pediatrics · 2022Review
- The Auxological and Metabolic Consequences for Children Born Small for Gestational Age.Indian journal of pediatrics · 2021Review
- Birth weight, childhood and adolescent growth and diabetes risk factors in 21-year-old Asian Indians: the Pune Children's Study.Journal of developmental origins of health and disease · 2021Article
83 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Type 2 (non-insulin-dependent) diabetes mellitus may originate through impaired development in fetal life. Both insulin deficiency and resistance to the action of insulin are thought to be important in its pathogenesis. Although there is evidence that impaired fetal development may result in insulin deficiency, it is not known whether insulin resistance could also be a consequence of reduced early growth. Insulin resistance was therefore measured in 81 normoglycaemic subjects, and 22 subjects with impaired glucose tolerance, who were born in Preston, UK, between 1935 and 1943. Their birth measurements had been recorded in detail. Insulin resistance was measured by the insulin tolerance test which uses the rate of fall in blood glucose concentrations after intravenous injection of insulin as an index of insulin resistance. Men and women who were thin at birth, as measured by a low ponderal index, were more insulin resistant. The association was statistically significant (p = 0.01) and independent of duration of gestation, adult body mass index and waist to hip ratio and of confounding variables including social class at birth or currently. Thinness at birth and in adult life has opposing effects such that resistance fell with increasing ponderal index at birth but rose with increasing adult body mass index. It is concluded that insulin resistance is associated with impaired development in fetal life.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.