ArticleProceedings of the National Academy of Sciences of the United States of America1994
Kinetics of an RNA conformational switch.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- AI-Enhanced Electrochemical Sensing Systems: A Paradigm Shift for Intelligent Food Safety Monitoring.Biosensors · 2025Review
- A transient intermediate RNA structure underlies the regulatory function of theRNA (New York, N.Y.) · 2023Article
- Tuning strand displacement kinetics enables programmable ZTP riboswitch dynamic range in vivo.Nucleic acids research · 2023Article
- Cotranscriptional RNA strand exchange underlies the gene regulation mechanism in a purine-sensing transcriptional riboswitch.Nucleic acids research · 2022Article
- IndelsRNAmute: predicting deleterious multiple point substitutions and indels mutations.BMC bioinformatics · 2022Article
- How does RNA fold dynamically?Journal of molecular biology · 2022Review
- Simulation of Folding Kinetics for Aligned RNAs.Genes · 2021Article
- How to measure and evaluate binding affinities.eLife · 2020Article
- Article
- A ligand-gated strand displacement mechanism for ZTP riboswitch transcription control.Nature chemical biology · 2019Article
- Probing RNA structure and interaction dynamics at the single molecule level.Methods (San Diego, Calif.) · 2019Review
- Study of E. coli Hfq's RNA annealing acceleration and duplex destabilization activities using substrates with different GC-contents.Nucleic acids research · 2013Article
- Efficient procedures for the numerical simulation of mid-size RNA kinetics.Algorithms for molecular biology : AMB · 2012Article
- Kinetic mechanism of conformational switch between bistable RNA hairpins.Journal of the American Chemical Society · 2012Article
- A conserved RNA pseudoknot in a putative molecular switch domain of the 3'-untranslated region of coronaviruses is only marginally stable.RNA (New York, N.Y.) · 2011Article
- Folding kinetics for the conformational switch between alternative RNA structures.The journal of physical chemistry. B · 2010Article
- Article
- mRNA secondary structures fold sequentially but exchange rapidly in vivo.PLoS biology · 2010Article
- An image processing approach to computing distances between RNA secondary structures dot plots.Algorithms for molecular biology : AMB · 2009Article
- Influence of C-5 halogenation of uridines on hairpin versus duplex RNA folding.RNA (New York, N.Y.) · 2007Article
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Authors and funding
2 authors.
Funding
Abstract
The spliced leader RNA from Leptomonas collosoma has two competing secondary structures of nearly equal free energy. Short, complementary oligonucleotides can drive the structure from one form of the other. We report stopped-flow rapid-mixing and temperature-jump measurements of the kinetics of the structural switch. At high concentrations of oligonucleotide, the rate of binding becomes limited by the rate of the structural switch, which occurs on a time scale of a fraction of a second. The low activation energy observed for the process implies a branch migration type of mechanism in which portions of the two competing helices transiently coexist.
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