ArticleProceedings of the National Academy of Sciences of the United States of America1994
Alpha-crystallin/small heat shock protein has autokinase activity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 136 citations in OpenAlex.
- Article
- Article
- Regulation of αA- and αB-crystallins via phosphorylation in cellular homeostasis.Cellular and molecular life sciences : CMLS · 2015Review
- Lens Biology and Biochemistry.Progress in molecular biology and translational science · 2015Review
- Article
- Article
- Phosphoproteomic differences in major depressive disorder postmortem brains indicate effects on synaptic function.European archives of psychiatry and clinical neuroscience · 2012Article
- Novel roles for α-crystallins in retinal function and disease.Progress in retinal and eye research · 2012Review
- αB-crystallin is elevated in highly infiltrative apoptosis-resistant glioblastoma cells.The American journal of pathology · 2010Article
- Transcriptional regulation of mouse alpha A-crystallin gene in a 148kb Cryaa BAC and its derivates.BMC developmental biology · 2008Article
- Differential expression of the catalytic subunits for PP-1 and PP-2A and the regulatory subunits for PP-2A in mouse eye.Molecular vision · 2008Article
- A new locus for autosomal dominant posterior polar cataract in Moroccan Jews maps to chromosome 14q22-23.Journal of medical genetics · 2006Article
- Calcium-activated RAF/MEK/ERK signaling pathway mediates p53-dependent apoptosis and is abrogated by alpha B-crystallin through inhibition of RAS activation.Molecular biology of the cell · 2005Article
- Expression of betaB(2)-crystallin mRNA and protein in retina, brain, and testis.Investigative ophthalmology & visual science · 2000Article
- The genetics of cataract: our vision becomes clearer.American journal of human genetics · 1998Article
- ATP-enhanced molecular chaperone functions of the small heat shock protein human alphaB crystallin.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Targeted disruption of the mouse alpha A-crystallin gene induces cataract and cytoplasmic inclusion bodies containing the small heat shock protein alpha B-crystallin.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Ceramide formation during heat shock: a potential mediator of alpha B-crystallin transcription.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Regulation of the murine alpha B-crystallin/small heat shock protein gene in cardiac muscle.Molecular and cellular biology · 1995Article
- Lens-specific activity of the mouse alpha A-crystallin promoter in the absence of a TATA box: functional and protein binding analysis of the mouse alpha A-crystallin PE1 region.Nucleic acids research · 1995Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The alpha-crystallins (alpha A and alpha B) are major water-soluble proteins of the transparent eye lens that are expressed in a variety of tissues and can function as molecular chaperones. alpha B-crystallin is also a small heat shock protein associated with numerous degenerative diseases and abnormal growth patterns. Previous experiments have shown that alpha A-and alpha B-crystallin are phosphorylated on specific serine residues by a cAMP-dependent pathway. Here we provide evidence that either total bovine alpha-crystallin or its isolated polypeptides can autophosphorylate serine by a cAMP-independent mechanism in the presence of Mg2+ and [gamma-32P]ATP; the autophosphorylated products isoelectrically focus with the authentic phosphorylated forms of the alpha-crystallin polypeptides. Thus, the alpha A- and alpha B-crystallin/small heat shock protein polypeptides are enzyme-crystallins which may be involved in metabolic pathways important for the development, maintenance, or pathology of the lens and other tissues.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.