ArticleProceedings of the National Academy of Sciences of the United States of America1994
Enterochromaffin cells of the digestive system: cellular source of guanylin, a guanylate cyclase-activating peptide.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 107 citations in OpenAlex.
- Enteroendocrine cell differentiation: Implications for human disease.Molecular and cellular endocrinology · 2025Review
- Gut reactions and gut instincts: regulation of intestinal homeostasis by receptor guanylyl cyclase C (GC-C).The Biochemical journal · 2025Review
- Enteroendocrine cell regulation of the gut-brain axis.Frontiers in neuroscience · 2023Review
- Dopamine receptors in emesis: Molecular mechanisms and potential therapeutic function.Pharmacological research · 2020Review
- Characterisation of proguanylin expressing cells in the intestine - evidence for constitutive luminal secretion.Scientific reports · 2019Article
- Interaction of Human Enterochromaffin Cells with Human Enteric Adenovirus 41 Leads to Serotonin Release and Subsequent Activation of Enteric Glia Cells.Journal of virology · 2018Article
- Guanylin and uroguanylin are produced by mouse intestinal epithelial cells of columnar and secretory lineage.Histochemistry and cell biology · 2016Article
- Cellular localization of guanylin and uroguanylin mRNAs in human and rat duodenal and colonic mucosa.Cell and tissue research · 2016Article
- Rotavirus and Serotonin Cross-Talk in Diarrhoea.PloS one · 2016Article
- Diagnosis of Irritable Bowel Syndrome: Role of Potential Biomarkers.Gastroenterology research and practice · 2015Review
- Identification of unique release kinetics of serotonin from guinea-pig and human enterochromaffin cells.The Journal of physiology · 2013Article
- Current understanding of guanylin peptides actions.ISRN nephrology · 2013Review
- Guanylin and functional coupling proteins in the hepatobiliary system of rat and guinea pig.Histochemistry and cell biology · 2012Article
- Rotavirus stimulates release of serotonin (5-HT) from human enterochromaffin cells and activates brain structures involved in nausea and vomiting.PLoS pathogens · 2011Article
- The diversity and commonalities of gastroenteropancreatic neuroendocrine tumors.Langenbeck's archives of surgery · 2011Review
- Article
- Regulation of electroneutral NaCl absorption by the small intestine.Annual review of physiology · 2011Review
- Gut hormones: emerging role in immune activation and inflammation.Clinical and experimental immunology · 2010Review
- Phosphate sensing.Current opinion in nephrology and hypertension · 2009Review
- Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Guanylin, a bioactive peptide, has recently been isolated from the intestine; this peptide activates intestinal guanylate cyclase (i.e., guanylate cyclase C) and thus is potentially involved in the regulation of water/electrolyte transport in the gastrointestinal mucosa. As yet, the cells involved in synthesis, storage, or secretion of guanylin have not been identified by immunocytochemistry. We raised antisera against guanylin and investigated the entire gastrointestinal tract of guinea pigs by light and electron microscopical immunocytochemistry. Extracts of various intestinal segments and plasma analyzed on a Western blot revealed a peptide band corresponding to the molecular mass of guanylin. Localization studies in the entire digestive tract showed that guanylin is exclusively confined to enterochromaffin (EC) cells. Remarkably, most EC cells contacted the gut lumen by cell processes that were highly immunoreactive for guanylin. In addition to the well known secretion in an endocrine fashion, EC cells by circumstantial evidence may release guanylin into the gut lumen to activate guanylate cyclase C that is immediately located on the brush border of adjacent enterocytes. The unique localization of guanylin in EC cells may indicate that these cells are involved in the regulation of fluid secretion in the gastrointestinal mucous membrane.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.