Evidence map›Paper›PMID 8157271›Full record

ArticleImmunology1994

Identification of a putative cellular receptor for feline immunodeficiency virus as the feline homologue of CD9.

B J Willett, M J Hosie, O Jarrett, J C Neil

Open access · greenAbstract read
In one paragraph

Article in Immunology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 66 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Strategies for targeting tetraspanin proteins: potential therapeutic applications in microbial infections.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2009
    Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Animal virus receptors.Folia microbiologica · 1999
    Review
  15. Article
  16. Mechanisms of enveloped virus entry into animal cells.Advanced drug delivery reviews · 1998
    Article
  17. Article
  18. Feline immunodeficiency virus infection: an overview.Veterinary journal (London, England : 1997) · 1998
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

B J WillettDepartment of Veterinary Pathology, University of Glasgow Veterinary School, U.K.
M J Hosie
O Jarrett
J C Neil
University of Glasgow · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

A monoclonal antibody vpg15 has been identified which recognizes a putative cellular receptor for feline immunodeficiency virus (FIV). The antibody immunoprecipitates a single 24,000 MW species from feline cells. The molecular size and pattern of expression of the ligand for the vpg15 antibody displayed similarities to that of the human leucocyte differentiation antigen CD9. The reactivity of the vpg15 antibody was therefore compared with that of the anti-human CD9 antibody FMC56, an antibody which cross-reacts with feline cells. Expression of the vpg15 ligand correlated well with the reactivity of the FMC56 antibody on peripheral blood leucocytes and a panel of feline cell lines. Furthermore, the anti-human CD9 antibody reacted with murine fibroblast cells which had been transfected with high molecular weight feline DNA and immunoselected with the vpg15 antibody. FMC56 and vpg15 immunoprecipitated a similar 24,000 MW species from surface-iodinated feline cells and depletion of the vpg15 ligand from cell lysates resulted in a corresponding depletion of the FMC56 ligand. The data demonstrate that the vpg15 antibody recognizes the feline homologue of human CD9 and implicate feline CD9 as a cellular receptor for FIV.

Indexed as

Membrane GlycoproteinsAnimalsAntibodies, MonoclonalAntigens, CDCatsCell LineHumansImmunodeficiency Virus, FelineLigandsMiceMolecular WeightPrecipitin TestsReceptors, VirusTetraspanin 29Antibodies, MonoclonalAntigens, CDCD9 protein, humanCd9 protein, mouseLigandsMembrane GlycoproteinsReceptors, VirusTetraspanin 29

Identifiers

PMID8157271
PMCPMC1422324
OpenAlexW2400439429

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.