ArticleThe EMBO journal1994
Differential transactivation potential of Oct1 and Oct2 is determined by additional B cell-specific activities.
Article in The EMBO journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 69 citations in OpenAlex.
- Btk expression is controlled by Oct and BOB.1/OBF.1.Nucleic acids research · 2006Article
- Myosin light chain 1 atrial isoform (MLC1A) is expressed in pre-B cells under control of the BOB.1/OBF.1 coactivator.Nucleic acids research · 2004Article
- BOB.1/OBF.1 deficiency affects marginal-zone B-cell compartment.Molecular and cellular biology · 2002Article
- Mouse lymphoid cell line selected to have high immunoglobulin promoter activity.Molecular and cellular biology · 2002Article
- Raf induces NF-kappaB by membrane shuttle kinase MEKK1, a signaling pathway critical for transformation.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Up-regulation of BOB.1/OBF.1 expression in normal germinal center B cells and germinal center-derived lymphomas.The American journal of pathology · 2000Article
- OCA-B is a functional analog of VP16 but targets a separate surface of the Oct-1 POU domain.Molecular and cellular biology · 1997Article
- POU domain transcription factors in embryonic development.Molecular biology reports · 1997Review
- The carboxy-terminal transactivation domain of Oct-4 acquires cell specificity through the POU domain.Molecular and cellular biology · 1997Article
- CRISP-3, a protein with homology to plant defense proteins, is expressed in mouse B cells under the control of Oct2.Molecular and cellular biology · 1996Article
- Gene structure and characterization of the murine homologue of the B cell-specific transcriptional coactivator OBF-1.Nucleic acids research · 1996Article
- Signal transduction into the nucleus: fifth colloquium on cellular signal transduction. Heidelberg, Germany, January 1996.Journal of cancer research and clinical oncology · 1996Article
- High mobility group protein 2 functionally interacts with the POU domains of octamer transcription factors.The EMBO journal · 1995Article
- Direct evidence that the POU family transcription factor Oct-2 represses the cellular tyrosine hydroxylase gene in neuronal cells.Journal of molecular neuroscience : MN · 1995Article
- Functional differences between the Oct2 transactivation domains determine the transactivation potential of individual Oct2 isoforms.Nucleic acids research · 1994Article
- Two distinct mechanisms contribute to the constitutive activation of RelB in lymphoid cells.The EMBO journal · 1994Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell type-specific transcriptional regulation is generally believed to be mediated by sequence-specific transcription factors that are specifically present in the corresponding cells. The interaction of the lymphoid-specific Oct2 transcription factor has been thought to be responsible for the B cell-specific activity of octamer-containing promoter and enhancer elements. Here we show that physiological concentrations of Oct2 do not suffice to generate octamer-dependent promoter activity in non-B cell lines. Furthermore, we have tested the activity of octamer-dependent promoter and enhancer elements in B cell lines that lack the endogenous Oct2 protein. Our results demonstrate that in these Oct2-deficient B cells the ubiquitous endogenous Oct1 protein is able to stimulate octamer-containing promoters to a level comparable with that of normal Oct2-positive B cells. However, reporter constructs bearing the octamer motif in a distal enhancer position are not stimulated by the Oct1 protein, but do require the presence of Oct2. The B cell-specific octamer-dependent promoter activity mediated by Oct1 correlates with the presence of a novel B cell-specific octamer-binding complex containing the Oct1 protein. From these results we conclude that B cells contain two different activities: one that interacts with both Oct1 and Oct2 and mediates promoter proximal activity of the octamer motif and a second that specifically interacts with Oct2 to confer function from a remote enhancer position.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.