Evidence map›Paper›PMID 8154937›Full record

ArticleAnnals of the rheumatic diseases1994

HLA-DP does not contribute towards susceptibility to systemic lupus erythematosus.

E J Davies, C J Hutchings, M C Hillarby, R P Donn, R G Cooper, E M Hay, R M Bernstein, P J Holt, D M Grennan, W E Ollier

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of the rheumatic diseases, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

E J DaviesUniversity of Manchester, Rheumatic Diseases Centre, Hope Hospital, Salford, United Kingdom.
C J Hutchings
M C Hillarby
R P Donn
R G Cooper
E M Hay
R M Bernstein
P J Holt
D M Grennan
W E Ollier
University of Manchester · GBSalford Royal Hospital · GBUniversity of Salford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo determine whether HLA-DP genes are involved in determining susceptibility to systemic lupus erythematosus (SLE).

methodsHLA-DPA1 and DPB1 genes were amplified by PCR of DNA samples from a panel of patients with SLE and normal controls. Amplified DNA was blotted on to nylon filters and probed with sequence-specific oligonucleotide (SSO) probes.

resultsNo DPA1 or DPB1 allele was significantly associated with SLE, or with any immunological or clinical subset of SLE. Evidence was found for only limited linkage disequilibrium between HLA-DP and HLA-DQ/DR variants, and none between HLA-DP and the TAP2 gene.

conclusionsThese data indicate that HLA-DP genes do not contribute towards determining susceptibility to SLE.

Indexed as

Genes, MHC Class IIAdolescentAdultAgedAllelesAutoantibodiesChildDisease SusceptibilityFemaleGene FrequencyHLA-DP AntigensHLA-DQ AntigensHLA-DR AntigensHumansLinkage DisequilibriumLupus Erythematosus, SystemicAutoantibodiesHLA-DP AntigensHLA-DQ AntigensHLA-DR Antigens

Identifiers

PMID8154937
PMCPMC1005284
OpenAlexW2157920865

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.