ArticleNucleic acids research1994
Involvement of SRE element of Ty1 transposon in TEC1-dependent transcriptional activation.
Article in Nucleic acids research, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 64 citations in OpenAlex.
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- Cdc42p-interacting protein Bem4p regulates the filamentous-growth mitogen-activated protein kinase pathway.Molecular and cellular biology · 2015Article
- Genetic circuits that govern bisexual and unisexual reproduction in Cryptococcus neoformans.PLoS genetics · 2013Article
- Tye7 regulates yeast Ty1 retrotransposon sense and antisense transcription in response to adenylic nucleotides stress.Nucleic acids research · 2012Article
- The regulation of filamentous growth in yeast.Genetics · 2012Review
- Multiple signals converge on a differentiation MAPK pathway.PLoS genetics · 2010Article
- The signaling mucins Msb2 and Hkr1 differentially regulate the filamentation mitogen-activated protein kinase pathway and contribute to a multimodal response.Molecular biology of the cell · 2009Article
- Remodeling yeast gene transcription by activating the Ty1 long terminal repeat retrotransposon under severe adenine deficiency.Molecular and cellular biology · 2008Article
- Cleavage of the signaling mucin Msb2 by the aspartyl protease Yps1 is required for MAPK activation in yeast.The Journal of cell biology · 2008Article
- Extracting expression modules from perturbational gene expression compendia.BMC systems biology · 2008Article
- A cryptic unstable transcript mediates transcriptional trans-silencing of the Ty1 retrotransposon in S. cerevisiae.Genes & development · 2008Article
- SREBP controls oxygen-dependent mobilization of retrotransposons in fission yeast.PLoS genetics · 2007Article
- Regulation of mating and filamentation genes by two distinct Ste12 complexes in Saccharomyces cerevisiae.Molecular and cellular biology · 2006Article
- Persistent activation by constitutive Ste7 promotes Kss1-mediated invasive growth but fails to support Fus3-dependent mating in yeast.Molecular and cellular biology · 2004Article
- A signaling mucin at the head of the Cdc42- and MAPK-dependent filamentous growth pathway in yeast.Genes & development · 2004Article
- Interaction of the E1A oncoprotein with Yak1p, a novel regulator of yeast pseudohyphal differentiation, and related mammalian kinases.Molecular biology of the cell · 2001Article
- Characterization of alcohol-induced filamentous growth in Saccharomyces cerevisiae.Molecular biology of the cell · 2000Article
- Regulation of G2/M progression by the STE mitogen-activated protein kinase pathway in budding yeast filamentous growth.Molecular biology of the cell · 1999Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Some Ty1 transposable element insertion mutations of Saccharomyces cerevisiae activate transcription of adjacent genes in a cell-type dependent manner. This activation requires at least STE12 and TEC1 gene products. The binding site for the STE12 protein is located in the sterile responsive element (SRE), which is just downstream the 5' LTR of Ty1 and contains one copy of the pheromone response element (PRE). This report defines the sequences in Ty1 required for TEC1-dependent activation using a TDH3::lacZ reporter gene in which the UAS was replaced by different portions of a Ty1 or Ty2 element. The Ty1 SRE seems to be sufficient to ensure the TEC1 and STE12-mediated activation whereas Ty2 SRE can activate the expression of the adjacent genes in the absence of both proteins. Adjacent to the PRE element, there is a region (PAE) with extensive sequence divergence in Ty1 and Ty2 SREs. Swapping experiments between Ty1 and Ty2 sequences show that Ty1 PAE is required for the activation of adjacent gene expression in a TEC1 and STE12-dependent manner. The use of a LexA::TEC1 construct indicates that the chimeric protein has no activation ability suggesting that TEC1 could act in conjunction with another factor.
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