ArticleNucleic acids research1994
Regulation of the Oct-4 gene by nuclear receptors.
Article in Nucleic acids research, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 88 citations in OpenAlex.
- An Effective Model of the Retinoic Acid Induced HL-60 Differentiation Program.Scientific reports · 2017Article
- A Structural Investigation into Oct4 Regulation by Orphan Nuclear Receptors, Germ Cell Nuclear Factor (GCNF), and Liver Receptor Homolog-1 (LRH-1).Journal of molecular biology · 2016Article
- Exposure to the widely used herbicide atrazine results in deregulation of global tissue-specific RNA transcription in the third generation and is associated with a global decrease of histone trimethylation in mice.Nucleic acids research · 2016Article
- Epigenetic silencing of Oct4 by a complex containing SUV39H1 and Oct4 pseudogene lncRNA.Nature communications · 2015Article
- RAR/RXR binding dynamics distinguish pluripotency from differentiation associated cis-regulatory elements.Nucleic acids research · 2015Article
- Gene structure and identification of minimal promoter of Pou2 expressed in spermatogonial cells of rohu carp, Labeo rohita.Molecular biology reports · 2014Article
- Regulatory potential of COUP-TFs in development: stem/progenitor cells.Seminars in cell & developmental biology · 2013Review
- Oct4 is required ~E7.5 for proliferation in the primitive streak.PLoS genetics · 2013Article
- Minireview: the diverse roles of nuclear receptors in the regulation of embryonic stem cell pluripotency.Molecular endocrinology (Baltimore, Md.) · 2013Review
- Rapid and efficient reprogramming of somatic cells to induced pluripotent stem cells by retinoic acid receptor gamma and liver receptor homolog 1.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Expression of Mirlet7 family microRNAs in response to retinoic acid-induced spermatogonial differentiation in mice.Biology of reproduction · 2011Article
- SAF-A has a role in transcriptional regulation of Oct4 in ES cells through promoter binding.Cellular reprogramming · 2011Article
- Evolution of gene regulation of pluripotency--the case for wiki tracks at genome browsers.Biology direct · 2010Article
- Retinoic acid accelerates downregulation of the Xist repressor, Oct4, and increases the likelihood of Xist activation when Tsix is deficient.BMC developmental biology · 2010Article
- Transcriptional regulation of the Oct4 gene, a master gene for pluripotency.Histology and histopathology · 2010Review
- RIP140 in thyroid hormone-repression and chromatin remodeling of Crabp1 gene during adipocyte differentiation.Nucleic acids research · 2009Article
- Linking DNA methylation and histone modification: patterns and paradigms.Nature reviews. Genetics · 2009Review
- Cloning and Characterization of 3.1kb Promoter Region of the Oct4 Gene from the Fischer 344 Rat.The open stem cell journal · 2009Article
- Co-localization of angiotensin-converting enzyme 2-, octomer-4- and CD34-positive cells in rabbit atherosclerotic plaques.Experimental physiology · 2008Article
- Structure and expression pattern of Oct4 gene are conserved in vole Microtus rossiaemeridionalis.BMC genomics · 2008Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To unravel the network of transcription factors established during development it is important to understand how genes specifically expressed during embryogenesis are regulated. Oct-4 is a transcription factor whose expression is associated with an undifferentiated cell phenotype in the early mouse embryo and is downregulated when such cells differentiate. An enhancer in the upstream region of Oct-4 has previously been reported as being sufficient to mediate the cell-type specific expression and RA-dependent down-regulation in EC cells, although the enhancer contains no retinoic acid receptor (RAR) binding sites. Here we report the identification of promoter elements important for the regulation of the Oct-4 gene in EC cells. A region of the proximal Oct-4 promoter contains an overlapping set of regulatory elements including a high affinity binding site for Sp1 and three direct repeats of an AGGTCA-like sequence with either +1 or 0 spacing. Binding and transient transfection assays reveal that Oct-4 is subject to negative regulation by different members of the steroid-thyroid hormone receptor superfamily. Specifically, important roles for ARP-1 and RAR in Oct-4 expression are indicated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.