ArticleNucleic acids research1994
Identification and characterization of a novel repressor site in the human tumor necrosis factor alpha gene.
Article in Nucleic acids research, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Association ofBioscience reports · 2018Pooled it
- Association between TNF-α polymorphisms and cervical cancer risk: a meta-analysis.Molecular biology reports · 2012Pooled it
- Association of OPG, TNF-α, and IL-1B Gene Variants With Periodontitis in a South African Population.International dental journal · 2026Observational
- TheInnate immunity · 2021Article
- Genetic polymorphisms in tumor necrosis factor alpha and interleukin-10 are associated with an increased risk of cervical cancer.International immunopharmacology · 2019Article
- The Correlation Between TNF-α Promoter Gene Polymorphism and Genetic Susceptibility to Cervical Cancer.Technology in cancer research & treatment · 2018Article
- Tumor Necrosis Factor Alpha (-238 / -308) and TNFRII-VNTR (-322) Polymorphisms as Genetic Biomarkers of Susceptibility to Develop Cervical Cancer Among Tunisians.Pathology oncology research : POR · 2015Article
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- TNF-α and IL-10 promoter polymorphisms, HPV infection, and cervical cancer risk.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2012Article
- Association study between functional polymorphisms in the TNF-alpha gene and obsessive-compulsive disorder.Arquivos de neuro-psiquiatria · 2012Article
- Functional differences exist between TNFα promoters encoding the common -237G SNP and the rarer HLA-B*5701-linked A variant.PloS one · 2012Article
- TNF-α Polymorphisms in Juvenile Idiopathic Arthritis: Which Potential Clinical Implications?International journal of rheumatology · 2012Article
- Genetic polymorphisms of innate immunity-related inflammatory pathways and their association with factors related to type 2 diabetes.BMC medical genetics · 2011Article
- Genetic and functional role of TNF-alpha in the development Trypanosoma cruzi infection.PLoS neglected tropical diseases · 2011Article
- Type 2 diabetes mellitus and inflammation: Prospects for biomarkers of risk and nutritional intervention.Diabetes, metabolic syndrome and obesity : targets and therapy · 2010Article
- Obesity-dependent association of TNF-LTA locus with type 2 diabetes in North Indians.Journal of molecular medicine (Berlin, Germany) · 2010Article
- TNF and LTA gene, allele, and extended HLA haplotype associations with severe dengue virus infection in ethnic Thais.The Journal of infectious diseases · 2009Article
- Rapid genotyping of tumor necrosis factor alpha with fluorogenic hybridization probes on the LightCycler.Clinical and experimental medicine · 2008Article
- Variants in mannose-binding lectin and tumour necrosis factor alpha affect survival in cystic fibrosis.Journal of medical genetics · 2007Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In human monocytic cell lines, tumor necrosis factor alpha (TNF alpha) expression is induced by phorbol myristate acetate (PMA). We have identified positive and negative cis-acting elements in the TNF alpha promoter by deletion analysis. Here we present the initial characterization of the repressor element. The repressor element was shown to function in either orientation and at various distances upstream from the positive element of the TNF alpha promoter. The TNF alpha repressor site (TRS) has been localized to a 25 bp region between base pairs -254 and -230 in the promoter. This region contains a 10 bp sequence with homology to the binding site of the activator protein AP-2. Mutation of the 6 C's of this 10 bp AP-2-like site abolish TRS repressor function. However, this AP-2-like site is not a binding site for AP-2 protein based on gel retardation analysis. In addition, a well-characterized AP-2-binding site placed upstream of the positive element of the TNF alpha gene did not cause repression. Therefore, this repression is very likely mediated by a novel protein(s) which interacts with the AP-2 consensus site in the TRS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.