ArticleNucleic acids research1994
A novel bipartite splicing enhancer modulates the differential processing of the human fibronectin EDA exon.
Article in Nucleic acids research, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
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Who cites it
79 citing papers in PubMed, 144 citations in OpenAlex.
- Evaluation of both exonic and intronic variants for effects on RNA splicing allows for accurate assessment of the effectiveness of precision therapies.PLoS genetics · 2020Article
- Splicing factors differentially expressed in psoriasis alter mRNA maturation of disease-associated EDA+ fibronectin.Molecular and cellular biochemistry · 2017Article
- Fibronectin maintains the balance between hemostasis and thrombosis.Cellular and molecular life sciences : CMLS · 2016Review
- The Dengue Virus NS5 Protein Intrudes in the Cellular Spliceosome and Modulates Splicing.PLoS pathogens · 2016Article
- The Role of Alternative Splicing in the Control of Immune Homeostasis and Cellular Differentiation.International journal of molecular sciences · 2015Review
- Binding site discovery from nucleic acid sequences by discriminative learning of hidden Markov models.Nucleic acids research · 2014Article
- Multiple tandem splicing silencer elements suppress aberrant splicing within the long exon 26 of the human Apolipoprotein B gene.BMC molecular biology · 2013Article
- The influence of autonomic dysfunction associated with aging and type 2 diabetes on daily life activities.Experimental diabetes research · 2012Review
- Predicting sequence and structural specificities of RNA binding regions recognized by splicing factor SRSF1.BMC genomics · 2011Article
- Cap-binding protein complex links pre-mRNA capping to transcription elongation and alternative splicing through positive transcription elongation factor b (P-TEFb).The Journal of biological chemistry · 2011Article
- Histone deacetylase activity modulates alternative splicing.PloS one · 2011Article
- The intronic splicing code: multiple factors involved in ATM pseudoexon definition.The EMBO journal · 2010Article
- Bipartite functions of the CREB co-activators selectively direct alternative splicing or transcriptional activation.The EMBO journal · 2009Article
- 7SK snRNP/P-TEFb couples transcription elongation with alternative splicing and is essential for vertebrate development.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Splicing factor SFRS1 recognizes a functionally diverse landscape of RNA transcripts.Genome research · 2009Article
- Identification of nuclear and cytoplasmic mRNA targets for the shuttling protein SF2/ASF.PloS one · 2008Article
- New insights into form and function of fibronectin splice variants.The Journal of pathology · 2008Review
- Influence of Friedreich ataxia GAA noncoding repeat expansions on pre-mRNA processing.American journal of human genetics · 2008Article
- Differing patterns of selection in alternative and constitutive splice sites.Genome research · 2007Article
- Cryptic splice site usage in exon 7 of the human fibrinogen Bbeta-chain gene is regulated by a naturally silent SF2/ASF binding site within this exon.RNA (New York, N.Y.) · 2006Article
19 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
EDA is a facultative type III homology of human fibronectin encoded by an alternative spliced exon. The EDA+ and EDA- mRNA forms show a cell type specific distribution with their relative proportion varying during development, aging and oncogenic transformation. We have previously demonstrated that an 81 bp nucleotide sequence within the exon itself is essential for differential RNA processing. Fine mapping of cis acting elements within this region has been carried out to identify possible target sites for the modulation of alternative splicing. There are at least two short nucleotide sequences involved. Element A (GAAGAAGA) is a positive modulator for the recognition of the exon, its deletion results in constitutive exclusion of the EDA exon. Element B (CAAGG) is a negative modulator for exon recognition, its deletion results in constitutive inclusion of the EDA exon. This bipartite structure of the splicing enhancer is a novel feature of the mammalian exons.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.