ArticleJournal of virology1994
Microglial infection by a neurovirulent murine retrovirus results in defective processing of envelope protein and intracellular budding of virus particles.
Article in Journal of virology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 38 citations in OpenAlex.
- Astrocyte Infection Is Required for Retrovirus-Induced Spongiform Neurodegeneration Despite Suppressed Viral Protein Expression.Frontiers in neuroscience · 2019Article
- Rebound from Inhibition: Self-Correction against Neurodegeneration?Journal of clinical & cellular immunology · 2017Article
- Postinhibitory rebound neurons and networks are disrupted in retrovirus-induced spongiform neurodegeneration.Journal of neurophysiology · 2014Article
- Unique N-linked glycosylation of CasBrE Env influences its stability, processing, and viral infectivity but not its neurotoxicity.Journal of virology · 2013Article
- Retrovirus-induced spongiform neurodegeneration is mediated by unique central nervous system viral targeting and expression of env alone.Journal of virology · 2011Article
- Pulse labeling and long-term tracing of newborn neurons in the adult subgranular zone.Cell research · 2011Article
- Misfolding of CasBrE SU is reversed by interactions with 4070A Env: implications for gammaretroviral neuropathogenesis.Retrovirology · 2010Article
- Expression of murine leukemia virus envelope protein is sufficient for the induction of apoptosis.Journal of virology · 2008Article
- Gene expression profiling of microglia infected by a highly neurovirulent murine leukemia virus: implications for neuropathogenesis.Retrovirology · 2006Article
- Rodent model systems for studies of HIV-1 associated dementia.Neurotoxicity research · 2005Review
- Mink epithelial cell killing by pathogenic murine leukemia viruses involves endoplasmic reticulum stress.Journal of virology · 2004Article
- Disparate regions of envelope protein regulate syncytium formation versus spongiform encephalopathy in neurological disease induced by murine leukemia virus TR.Journal of virology · 2004Article
- Endoplasmic reticulum stress is a determinant of retrovirus-induced spongiform neurodegeneration.Journal of virology · 2003Article
- Abundant defective viral particles budding from microglia in the course of retroviral spongiform encephalopathy.Journal of virology · 2000Article
- Differential glycosylation of the Cas-Br-E env protein is associated with retrovirus-induced spongiform neurodegeneration.Journal of virology · 2000Review
- Neural stem cells as engraftable packaging lines can mediate gene delivery to microglia: evidence from studying retroviral env-related neurodegeneration.Journal of virology · 1999Article
- Neurovirulence in feline immunodeficiency virus-infected neonatal cats is viral strain specific and dependent on systemic immune suppression.Journal of virology · 1998Article
- Retrotransposition of nonviral RNAs in an avian packaging cell line.Journal of virology · 1998Article
- Late virus replication events in microglia are required for neurovirulent retrovirus-induced spongiform neurodegeneration: evidence from neural progenitor-derived chimeric mouse brains.Journal of virology · 1996Article
- A mechanism of restricted human immunodeficiency virus type 1 expression in human glial cells.Journal of virology · 1996Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The observation of murine retrovirus infection of microglial cells in brain regions expressing spongiform neurodegenerative changes suggests that these cells may play an important role in pathogenesis. To evaluate this potential in vitro, murine microglial cells were infected in mixed glial cultures with the highly neurovirulent murine retrovirus, FrCasE. The microglia were then isolated from the mixed cultures on the basis of their differential adherence and shown to be approximately 98% pure. The infected microglia expressed viral envelope protein at the plasma membrane, while viral budding was primarily intracellular. Evaluation of the viral envelope protein by immunoblotting indicated that the immunoreactive species produced was exclusively a 90-kDa precursor protein. Very little of the envelope protein was associated with particles released from these cells, and viral titers in the culture supernatant were low. Interestingly, these cells were still capable of infecting permissive target cells when seeded as infectious centers. This partially defective infection of microglial cells suggests a potential cellular means by which a neurovirulent retrovirus could disrupt normal microglia and in turn central nervous system motor system functioning.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.