ArticleEuropean biophysics journal : EBJ1994
A model of microtubule oscillations.
Article in European biophysics journal : EBJ, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Localized discrete and asymmetric dark-bright soliton-like modes as nonlinear dynamics in microtubules.Heliyon · 2024Article
- Live visualizations of single isolated tubulin protein self-assembly via tunneling current: effect of electromagnetic pumping during spontaneous growth of microtubule.Scientific reports · 2014Article
- Microtubule-like properties of the bacterial actin homolog ParM-R1.The Journal of biological chemistry · 2012Article
- The tempered polymerization of human neuroserpin.PloS one · 2012Article
- A multistranded polymer model explains MinDE dynamics in E. coli cell division.Biophysical journal · 2007Article
- A model for intracellular trafficking of adenoviral vectors.Biophysical journal · 2005Article
- Microtubule Dynamics may Embody a Stationary Bipolarity Forming Mechanism Related to the Prokaryotic Division Site Mechanism (Pole-to-Pole Oscillations).Journal of biological physics · 2004Article
- A Landau-Ginzburg Model of the Co-existence of Free Tubulin and Assembled Microtubules in Nucleation and Oscillations Phenomena.Journal of biological physics · 2000Article
- Models of assembly and disassembly of individual microtubules: stochastic and averaged equations.Journal of biological physics · 1999Article
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Authors and funding
2 authors.
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Abstract
Simulations of microtubule oscillations have been obtained by a kinetic model including nucleation of microtubules, elongation by addition of GTP-loaded tubulin dimers, disassembly into oligomers, and dissolution of oligomers followed by nucleotide exchange at the free dimers. Dynamic instability is described by the on and off rates for dimer association in the growth phase, the rate of rapid shortening, and the transition rates for catastrophe and rescue. The latter are assumed to be completely determined by the current state of the system ("short cap hypothesis"). Microtubule oscillations and normal polymerizations measured by time-resolved X-ray scattering were used to test the model. The model is able to produce oscillations without further assumptions. However, in order to obtain good fits to the experimental data one requires an additional mechanism which prevents rapid desynchronization of the microtubules. One of several possible mechanisms that will be discussed is the destabilization of microtubules by the products of disassembly.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.