ArticleArchives of internal medicine1994
Lp(a) lipoprotein is an independent, discriminating risk factor for premature peripheral atherosclerosis among white men.
Article in Archives of internal medicine, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 115 citations in OpenAlex.
- Lipoprotein(a) as a Risk Factor for Cardiovascular Diseases: Pathophysiology and Treatment Perspectives.International journal of environmental research and public health · 2023Review
- Association of Lipoprotein(a) Levels With Incidence of Major Adverse Limb Events.JAMA network open · 2022Article
- Plasma Lipoprotein(a) Levels as Determinants of Arterial Stiffening in Hypertension.Biomedicines · 2021Article
- Epidemiology of Peripheral Artery Disease and Polyvascular Disease.Circulation research · 2021Article
- Role of lipoprotein (a) in peripheral arterial disease.Annals of translational medicine · 2019Article
- Biomarkers and Genetics in Peripheral Artery Disease.Clinical chemistry · 2017Review
- Lipoprotein (a) as a cause of cardiovascular disease: insights from epidemiology, genetics, and biology.Journal of lipid research · 2016Review
- HyperLp(a)lipoproteinaemia: unmet need of diagnosis and treatment?Blood transfusion = Trasfusione del sangue · 2016Article
- Novel markers of peripheral arterial disease.Vascular medicine (London, England) · 2009Review
- Lipoprotein(a) was an independent predictor for major coronary events in treated hypertensive men.Clinical cardiology · 2002Article
- Lipoprotein(a) is related to the extent of lesions in the coronary vasculature and to unstable coronary syndromes.Clinical cardiology · 2000Article
- Effects of exercise on lipoprotein(a).Sports medicine (Auckland, N.Z.) · 1999Review
- Lipoprotein(a): An independent, genetic, and causal factor for cardiovascular disease and acute myocardial infarction.Indian heart journalReview
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundElevated plasma levels of Lp(a) lipoprotein have been linked to the development of premature atherosclerosis in the coronary circulation (coronary artery disease [CAD]). Although Lp(a) lipoprotein has been implicated as a risk factor for premature atherosclerosis in other locations, the patient populations described were not carefully screened for the coexistence of premature CAD. The purpose of this prospective study was to determine whether carefully screened patients with premature peripheral vascular disease (PVD) have elevated plasma levels of Lp(a) lipoprotein and to test the relative strength of Lp(a) lipoprotein level as a risk factor for premature PVD.
methodsWe studied 55 consecutive white men with premature PVD (onset at 45 years of age or earlier) presenting to our vascular laboratory. Study subjects were substratified into 17 with PVD only and 38 with combined PVD and CAD (PVD + CAD). Two comparison groups included 26 age-matched white men with premature CAD recruited from the Cardiology Service after cardiac catheterization and 32 age-matched white male controls recruited from outpatient clinics.
resultsMean plasma apolipoprotein B-100 levels were higher in the CAD group than in controls (P = .013). Mean plasma Lp(a) lipoprotein levels were higher among the 17 patients with PVD only than among controls (P = .008). The covariance-adjusted mean Lp(a) lipoprotein levels were higher among all 55 patients with PVD than among controls (P = .014). Logistic regression analysis demonstrated two variables to be significantly related to premature PVD: Lp(a) lipoprotein level greater than 30 mg/dL (odds ratio, 3.9; 95% confidence interval, 1.1 to 13.7) and apolipoprotein B level greater than 95 mg/dL (odds ratio, 3.2; 95% confidence interval, 1.0 to 10.0).
conclusionsLp(a) lipoprotein level is an independent, discriminating risk factor for premature PVD among white men.
Indexed as
Identifiers
8147686W2116750906What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.