ArticleProceedings of the National Academy of Sciences of the United States of America1994
A molecular model for the genetic and phenotypic characteristics of the mouse lethal yellow (Ay) mutation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 191 citations in OpenAlex.
- Ghost trade-offs: negative correlations between beneficial traits may be caused by other mechanisms than trade-offs.Theory in biosciences = Theorie in den Biowissenschaften · 2026Review
- Contribution of animal models to diabetes research: Its history, significance, and translation to humans.Journal of diabetes investigation · 2023Review
- RALY regulate the proliferation and expression of immune/inflammatory response genes via alternative splicing of FOS.Genes and immunity · 2022Article
- PFOA-Induced Ovotoxicity Differs Between Lean and Obese Mice With Impacts on Ovarian Reproductive and DNA Damage Sensing and Repair Proteins.Toxicological sciences : an official journal of the Society of Toxicology · 2022Article
- Metabolic Syndrome: Lessons from Rodent andBioMed research international · 2022Review
- Signatures of mitonuclear coevolution in a warbler species complex.Nature communications · 2021Article
- Selection on a small genomic region underpins differentiation in multiple color traits between two warbler species.Evolution letters · 2020Article
- An Independent Locus Upstream ofGenes · 2020Article
- Two new structural mutations in the 5' region of the ASIP gene cause diluted feather color phenotypes in Japanese quail.Genetics, selection, evolution : GSE · 2019Article
- Polymorphisms of theArchives animal breeding · 2019Article
- Identification and dynamic changes of RNAs isolated from RALY-containing ribonucleoprotein complexes.Nucleic acids research · 2017Article
- 60 YEARS OF POMC: Regulation of feeding and energy homeostasis by α-MSH.Journal of molecular endocrinology · 2016Review
- Melanocortin 1 Receptor: Structure, Function, and Regulation.Frontiers in genetics · 2016Review
- Genetics of skin color variation in Europeans: genome-wide association studies with functional follow-up.Human genetics · 2015Article
- Effect of the Y chromosome on testis weight in mice.The Journal of veterinary medical science · 2015Article
- Effects of post-weaning diet on metabolic parameters and DNA methylation status of the cryptic promoter in the A(vy) allele of viable yellow mice.The Journal of nutritional biochemistry · 2015Article
- Further characterization of diabetes mellitus and body weight loss in males of the congenic mouse strain DDD.Cg-A(y.).The Journal of veterinary medical science · 2015Article
- Progressive obesity alters ovarian folliculogenesis with impacts on pro-inflammatory and steroidogenic signaling in female mice.Biology of reproduction · 2014Article
- Genetic and epigenetic control of metabolic health.Molecular metabolism · 2013Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Lethal yellow (Ay) is a mutation at the mouse agouti locus in chromosome 2 that causes a number of dominant pleiotropic effects, including a completely yellow coat color, obesity, an insulin-resistant type II diabetic condition, and an increased propensity to develop a variety of spontaneous and induced tumors. Additionally, homozygosity for Ay results in preimplantation lethality, which terminates development by the blastocyst stage. The Ay mutation is the result of a 170-kb deletion that removes all but the promoter and noncoding first exon of another gene called Raly, which lies in the same transcriptional orientation as agouti and maps 280 kb proximal to the 3' end of the agouti gene. We present a model for the structure of the Ay allele that can explain the dominant pleiotropic effects associated with this mutation, as well as the recessive lethality, which is unrelated to the agouti gene.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.