ArticleThe Journal of physiology1993
Modulation by histamine of an inwardly rectifying potassium channel in human endothelial cells.
Article in The Journal of physiology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 43 citations in OpenAlex.
- Kir Channel Molecular Physiology, Pharmacology, and Therapeutic Implications.Handbook of experimental pharmacology · 2021Review
- Lipopolysaccharides increase Kir2.1 expression in lung endothelial cells.International journal of clinical and experimental pathology · 2018Article
- Effects of Ca2+-activated potassium and inward rectifier potassium channel on the differentiation of endothelial progenitor cells from human peripheral blood.Molecular biology reports · 2014Article
- Histamine promotes excitability in bovine adrenal chromaffin cells by inhibiting an M-current.The Journal of physiology · 2002Article
- Modulation of inwardly rectifying potassium channels in cultured bovine pulmonary artery endothelial cells.The Journal of physiology · 1997Article
- Membrane currents and the resting membrane potential in cultured bovine pulmonary artery endothelial cells.The Journal of physiology · 1996Article
- Inwardly rectifying K+ channels in freshly dissociated coronary endothelial cells from guinea-pig heart.The Journal of physiology · 1996Article
- Physiological and molecular characterization of an IRK-type inward rectifier K+ channel in a tumour mast cell line.Pflugers Archiv : European journal of physiology · 1995Article
- The inwardly rectifying potassium current of embryonic chick hepatocytes.The Journal of membrane biology · 1995Article
- Permeation properties and modulation of volume-activated Cl(-)-currents in human endothelial cells.British journal of pharmacology · 1994Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Whole-cell and single-channel currents were recorded together with intracellular Ca2+ in voltage clamped, single endothelial cells isolated from human umbilical vein. 2. The major current component under resting conditions in the whole-cell configuration was a strongly inwardly rectifying potassium current. 3. This current is due to activation of a K+ channel with an inward conductance of 29 +/- 3 pS (n = 7) with symmetrical 140 mM K+ on both sides of the membrane. This channel could be measured both in the cell-attached and in the inside-out configuration. At potentials below -110 mV both whole-cell and averaged single-channel currents showed a fast inactivation. 4. During stimulation of endothelial cells with histamine, whole-cell K+ currents initially increased but then substantially declined, despite the sustained increase in intracellular Ca2+ concentration ([Ca2+]i). 5. The blockade of the inwardly rectifying K+ channel by histamine could not be observed in cell-attached patches if histamine was added to the bath. 6. It is concluded that endothelial cells possess K+ channels that are directly inhibited by agonists, such as histamine. Blocking these channels may depolarize the cell membrane and thereby reduce the driving force for Ca2+ influx.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.