ReviewJournal of bioenergetics and biomembranes1993
Na+/H+ antiporters, molecular devices that couple the Na+ and H+ circulation in cells.
Review in Journal of bioenergetics and biomembranes, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 86 citations in OpenAlex.
- Gut Microbiota as a Mediator of Dietary Salt Effects on Blood Pressure.International journal of molecular sciences · 2026Review
- Biodesalination using halophytic cyanobacterium Phormidium keutzingianum from brackish to the hypersaline water.Chemosphere · 2022Article
- Architecture of bacterial respiratory chains.Nature reviews. Microbiology · 2021Review
- Insight into the direct interaction of NaScientific reports · 2021Article
- Revealing the salinity adaptation mechanism in halotolerant bacterium Egicoccus halophilus EGI 80432Applied microbiology and biotechnology · 2021Article
- Osmoregulation in the Halophilic Bacterium Halomonas elongata: A Case Study for Integrative Systems Biology.PloS one · 2017Article
- Revealing the ligand binding site of NhaA Na+/H+ antiporter and its pH dependence.The Journal of biological chemistry · 2012Article
- Genomes of surface isolates of Alteromonas macleodii: the life of a widespread marine opportunistic copiotroph.Scientific reports · 2012Article
- New insights in the sugarcane transcriptome responding to drought stress as revealed by superSAGE.TheScientificWorldJournal · 2012Article
- Genomic and proteomic analysis of the Alkali-Tolerance Response (AlTR) in Listeria monocytogenes 10403S.BMC microbiology · 2008Article
- NhaD type sodium/proton-antiporter of Halomonas elongata: a salt stress response mechanism in marine habitats?Saline systems · 2006Article
- Alkaline pH homeostasis in bacteria: new insights.Biochimica et biophysica acta · 2005Review
- The solution structure of ChaB, a putative membrane ion antiporter regulator from Escherichia coli.BMC structural biology · 2004Article
- Article
- The Na+-translocating NADH:quinone oxidoreductase (NDH I) from Klebsiella pneumoniae and Escherichia coli: implications for the mechanism of redox-driven cation translocation by complex I.Journal of bioenergetics and biomembranes · 2001Review
- Transcription of nhaA, the main Na(+)/H(+) antiporter of Escherichia coli, is regulated by Na(+) and growth phase.Journal of bacteriology · 2001Article
- Linkage map of Escherichia coli K-12, edition 10: the traditional map.Microbiology and molecular biology reviews : MMBR · 1998Review
- Perturbation of anion balance during inhibition of growth of Escherichia coli by weak acids.Journal of bacteriology · 1998Article
- Role of the nhaC-encoded Na+/H+ antiporter of alkaliphilic Bacillus firmus OF4.Journal of bacteriology · 1997Article
- Na+-induced transcription of nhaA, which encodes an Na+/H+ antiporter in Escherichia coli, is positively regulated by nhaR and affected by hns.Journal of bacteriology · 1996Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Na+/H+ antiporters are universal devices involved in the Na+ and H+ circulation of both eukaryotes and prokaryotes, thus playing an essential role in the pH and Na+ homeostasis of cells. This review focuses on the major impact of the application of molecular biology tools in the study of the antiporters. These tools permit the verification of the role of the antiporters and provide insights into their unique biology. A novel signal transduction to Na+ involving nhaR, a positive regulator, controls the expression of nhaA in E. coli. A "pH sensor" regulates the activity of Na+/H+ antiporters, both in eukaryotes and prokaryotes. A most intricate signal transduction to pH involving phosphorylation steps controls the activity of nhel in higher mammals. The identification of Histidine 226 in the "pH sensor" of NhaA is a step forward towards the understanding of the pH regulation of these proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.