ArticleJournal of bacteriology1994
Mutations which alter the kinetics of calcium transport alter the regulation of competence in Streptococcus pneumoniae.
Article in Journal of bacteriology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 40 citations in OpenAlex.
- Calcium RescuesMicroorganisms · 2024Article
- Different lanthanide elements induce strong gene expression changes in a lanthanide-accumulating methylotroph.Microbiology spectrum · 2023Article
- The Influence of Calcium on the Growth, Morphology and Gene Regulation inMicroorganisms · 2022Article
- Bacterial Second Messenger Cyclic di-AMP Modulates the Competence State in Streptococcus pneumoniae.Journal of bacteriology · 2020Article
- Involvement of minerals in adherence of Legionella pneumophila to surfaces.Current microbiology · 2013Article
- A novel initiation mechanism of death in Streptococcus pneumoniae induced by the human milk protein-lipid complex HAMLET and activated during physiological death.The Journal of biological chemistry · 2012Article
- Calciomics: prediction and analysis of EF-hand calcium binding proteins by protein engineering.Science China. Chemistry · 2010Article
- Calcium efflux is essential for bacterial survival in the eukaryotic host.Molecular microbiology · 2008Article
- Protein serine/threonine kinase StkP positively controls virulence and competence in Streptococcus pneumoniae.Infection and immunity · 2004Article
- RegR, a global LacI/GalR family regulator, modulates virulence and competence in Streptococcus pneumoniae.Infection and immunity · 2003Article
- Inorganic cation transport and energy transduction in Enterococcus hirae and other streptococci.Microbiology and molecular biology reviews : MMBR · 1998Review
- Calcium signalling in bacteria.Journal of bacteriology · 1996Review
- [Evolution of mechanisms of Calcium signaling: the role of Calcium ions in signal transduction in prokaryotes].Zhurnal evoliutsionnoi biokhimii i fiziologiiReview
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Streptococcus pneumoniae, Ca2+ induces a stress response which is regulated by a proteic activator known as competence factor (CF). This stress response is expressed as the induction of competence for DNA uptake and genetic transformation in exponentially growing cultures and by autolysis in late exponential phase. DNA transport during competence can be described as a homeostatic response that prevents autolysis of the cultures. Electrogenic and cooperative calcium transport with a Hill number (nH) of 2 appears to mediate this Ca2+ response. Mutant strains altered in their kinetics for Ca2+ transport, with nHs of 1 and 4, were isolated and characterized in order to address the role of the kinetics of Ca2+ transport in the Ca2+ response. The reduced cooperativity of Ca2+ uptake in mutant strain Cp2200 was associated with an absolute requirement for added CF to develop competence and with resistance to autolysis. The enhanced cooperativity of Ca2+ uptake in mutant strain Cp3300 was associated with facilitated competence and hypersensitivity to autolysis. Moreover, the mutation carried by strain Cp3300 increases the CF response of previously described competence-defective mutants. The pleiotropic mutants Cp2200 and Cp3300 allowed us to demonstrate that cooperativity of transport determines the Ca2+ response in S. pneumoniae.
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