ReviewExperientia1994
Transcription, topoisomerases and recombination.
Review in Experientia, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 40 citations in OpenAlex.
- Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Role for topoisomerase 1 in transcription-associated mutagenesis in yeast.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Article
- The absence of Top3 reveals an interaction between the Sgs1 and Pif1 DNA helicases in Saccharomyces cerevisiae.Genetics · 2006Article
- Impairment of replication fork progression mediates RNA polII transcription-associated recombination.The EMBO journal · 2005Article
- Human topoisomerase I mediates illegitimate recombination leading to DNA insertion into the ribosomal DNA locus in Saccharomyces cerevisiae.Molecular genetics and genomics : MGG · 2004Article
- Stimulation of mitotic recombination events by high levels of RNA polymerase II transcription in yeast.Molecular and cellular biology · 2000Article
- Human RecQ5beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3alpha and 3beta.Nucleic acids research · 2000Article
- The essential role of yeast topoisomerase III in meiosis depends on recombination.The EMBO journal · 1999Article
- Transcription through a simple DNA repeat blocks replication elongation.The EMBO journal · 1998Article
- Overexpression of a truncated human topoisomerase III partially corrects multiple aspects of the ataxia-telangiectasia phenotype.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Induction of Ty recombination in yeast by cDNA and transcription: role of the RAD1 and RAD52 genes.Genetics · 1996Article
- An element in the endogenous IgH locus stimulates gene targeting in hybridoma cells.Nucleic acids research · 1996Article
- Topoisomerase I involvement in illegitimate recombination in Saccharomyces cerevisiae.Molecular and cellular biology · 1996Article
- Gene conversion plays the major role in controlling the stability of large tandem repeats in yeast.The EMBO journal · 1996Article
- Requirements for activity of the yeast mitotic recombination hotspot HOT1: RNA polymerase I and multiple cis-acting sequences.Genetics · 1995Article
- Somatic intrachromosomal homologous recombination events in populations of plant siblings.Plant molecular biology · 1995Article
- The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyrase.Molecular and cellular biology · 1994Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcription, DNA topoisomerases and genetic recombination are interrelated for several structural reasons. Transcription can affect DNA topology, resulting in effects on recombination. It can also affect the chromatin structure in which the DNA resides. Topoisomerases can affect DNA and/or chromatin structure influencing the recombination potential at a given site. Here we briefly review the extent to which homologous direct repeat recombination and site-specific recombination in eukaryotes are affected by transcription and topoisomerases. In some cases, transcription or the absence of topoisomerases have little or no effect on recombination. In others, they are important components in the recombinational process. The common denominator of any effects of transcription and topoisomerases on recombination is their shared role in altering DNA topology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.