ReviewProtein science : a publication of the Protein Society1994
G proteins: critical control points for transmembrane signals.
Review in Protein science : a publication of the Protein Society, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 131 citations in OpenAlex.
- The NaThe Journal of veterinary medical science · 2026Review
- A novel missense variant of the GNAI3 gene and recognisable morphological characteristics of the mandibula in ARCND1.Journal of human genetics · 2021Article
- The CC and CXC chemokines: major regulators of tumor progression and the tumor microenvironment.American journal of physiology. Cell physiology · 2020Review
- Genetic behavioral screen identifies an orphan anti-opioid system.Science (New York, N.Y.) · 2019Article
- Biological and Pharmacological Aspects of the NK1-Receptor.BioMed research international · 2015Review
- An introduction to murine models of atrial fibrillation.Frontiers in physiology · 2012Article
- Differential response to morphine of the oligomeric state of μ-opioid in the presence of δ-opioid receptors.Biochemistry · 2011Article
- Polycystin-1 protein level determines activity of the Galpha12/JNK apoptosis pathway.The Journal of biological chemistry · 2010Article
- Evidence for a second, high affinity Gbetagamma binding site on Galphai1(GDP) subunits.The Journal of biological chemistry · 2009Article
- The R7 RGS protein family: multi-subunit regulators of neuronal G protein signaling.Cell biochemistry and biophysics · 2009Review
- Retinal ON bipolar cells express a new PCP2 splice variant that accelerates the light response.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Article
- Mutation of cysteine 214 in Gi1 alpha subunit abolishes its endogenous GTPase activity.The Biochemical journal · 2004Article
- Involvement of both G(q/11) and G(s) proteins in gonadotropin-releasing hormone receptor-mediated signaling in L beta T2 cells.The Journal of biological chemistry · 2002Article
- Light response of retinal ON bipolar cells requires a specific splice variant of Galpha(o).The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Hormonal regulation and implication of cell signaling in calcium transfer by placenta.Endocrine · 2001Review
- Inhibition of human platelet adenylate cyclase activity by adrenaline, thrombin and collagen: analysis and reinterpretation of experimental data.The Biochemical journal · 1999Article
- Article
- Coupling of D1 and D5 dopamine receptors to multiple G proteins: Implications for understanding the diversity in receptor-G protein coupling.Molecular neurobiology · 1998Review
- Activation of protein kinase A-independent pathways by Gs alpha in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Heterotrimeric GTP-binding proteins (G proteins) that are made up of alpha and beta gamma subunits couple many kinds of cell-surface receptors to intracellular effector enzymes or ion channels. Every cell contains several types of receptors, G proteins, and effectors. The specificity with which G protein subunits interact with receptors and effectors defines the range of responses a cell is able to make to an external signal. Thus, the G proteins act as a critical control point that determines whether a signal spreads through several pathways or is focused to a single pathway. In this review, I will summarize some features of the structure and function of mammalian G protein subunits, discuss the role of both alpha and beta gamma subunits in regulation of effectors, the role of the beta gamma subunit in macromolecular assembly, and the mechanisms that might make some responses extremely specific and others rather diffuse.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.