ArticleBritish journal of cancer1994
p53 mutations in cervical carcinogenesis--low frequency and lack of correlation with human papillomavirus status.
Article in British journal of cancer, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 72 citations in OpenAlex.
- Treatment algorithm and prognostic factors for patients with stage I-III carcinoma of the anal canal: a 20-year multicenter study.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2021Article
- High-Risk Human Papillomavirus and Tobacco Smoke Interactions in Epithelial Carcinogenesis.Cancers · 2020Review
- Comprehensive Data of P53 R282 Gene Mutation with Human Papillomaviruses (HPV)-Associated Oral Squamous Cell Carcinoma (OSCC).Pathology oncology research : POR · 2020Article
- The Role of p53 Gene in Cervical Carcinogenesis.Journal of obstetrics and gynaecology of India · 2016Article
- Cytogenetic significance of chromosome 17 aberrations and P53 gene mutations as prognostic markers in oral squamous cell carcinoma.Diagnostic pathology · 2015Article
- HPV subtypes in cervical cancer biopsies between 1930 and 2004: detection using general primer pair PCR and sequencing.Virchows Archiv : an international journal of pathology · 2006Article
- The bone morphogenetic protein antagonist gremlin 1 is overexpressed in human cancers and interacts with YWHAH protein.BMC cancer · 2006Article
- Aberrant cell cycle regulation in cervical carcinoma.Yonsei medical journal · 2005Review
- Article
- Limitations of the use of single base changes in the p53 gene to detect minimal residual disease of breast cancer.Molecular pathology : MP · 2002Article
- Anal cancer in Chinese: human papillomavirus infection and altered expression of p53.World journal of gastroenterology · 1998Article
- Mutations in the TP53 gene and protein expression of p53, MDM 2 and p21/WAF-1 in primary cervical carcinomas with no or low human papillomavirus load.British journal of cancer · 1998Article
- Post-transcriptional induction of p21cip1 protein in condylomata and dysplasias is inversely related to human papillomavirus activities.The American journal of pathology · 1998Article
- Aetiology, pathogenesis, and pathology of cervical neoplasia.Journal of clinical pathology · 1998Review
- Relation between retinoblastoma and p53 proteins in human papilloma viruses 16/18 positive and negative cancers of the uterine cervix.Journal of clinical pathology · 1997Article
- Abnormal expression and mutation of p53 in cervical cancer--a study at protein, RNA and DNA levels.Genitourinary medicine · 1997Article
- p53 expression in carcinoma of the cervix.Journal of clinical pathology · 1996Article
- Human papillomavirus DNA and TP53 mutations in lung cancers from butchers.British journal of cancer · 1995Article
- Progression of cervical intraepithelial neoplasia to cervical cancer: interactions of cytochrome P450 CYP2D6 EM and glutathione s-transferase GSTM1 null genotypes and cigarette smoking.British journal of cancer · 1994Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
p53 gene aberrations are common in human malignancies, and recent studies suggest that in cervical carcinoma p53 function is inactivated either by complex formation with human papillomavirus (HPV) E6 product or by gene mutation. Using polymerase chain reaction (PCR) followed by denaturing gradient gel electrophoresis (DGGE), we examined the mutational status of the four 'hotspot' regions of the p53 gene in 47 primary cervical carcinomas. HPV status was determined, also by PCR. In 20 of these cases, we examined for loss of heterozygosity (LOH) on chromosome 17p13. In the 47 carcinomas, and in a further 68 biopsy specimens from normal, premalignant and malignant cervix, we investigated aberrant immunocytochemical expression of p53. Immunocytochemically, abnormal p53 expression was detected in 13 of 115 cases (8/57 carcinomas). Somatic mutation in p53 was detected in 1 of 47 cervical carcinomas; 36 were positive for HPV 16, 18 or 33. A low level of allele loss (3 out of 20 cases) was detected on chromosome 17p, occurring in both HPV-positive and HPV-negative cases, and in cases with and without p53 mutations. We conclude that somatic mutation in the hotspot regions of the p53 gene occurs infrequently in cervical carcinomas; that immunocytochemically detectable levels of p53 are also infrequent; and that there is no consistent correlation between p53 mutational status, LOH on chromosome 17p or HPV status in these cancers.
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