ArticleActa neuropathologica1994
Jun, Fos, MyoD1, and myogenin proteins are increased in skeletal muscle fiber nuclei after denervation.
Article in Acta neuropathologica, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 54 citations in OpenAlex.
- Single-nucleus transcriptomics reveals subsets of degenerative myonuclei after rotator cuff tear-induced muscle atrophy.Cell proliferation · 2025Article
- Non-coding Transcripts from Enhancers: New Insights into Enhancer Activity and Gene Expression Regulation.Genomics, proteomics & bioinformatics · 2017Review
- A direct HDAC4-MAP kinase crosstalk activates muscle atrophy program.Molecular cell · 2012Article
- [Neurogenic muscular atrophy and selective fibre type atrophies : Groundbreaking findings in the biopsy diagnosis of neuromuscular disease].Der Pathologe · 2009Review
- MyoD- and nerve-dependent maintenance of MyoD expression in mature muscle fibres acts through the DRR/PRR element.BMC developmental biology · 2008Article
- The expression profile of myogenic transcription factors in satellite cells from denervated rat muscle.Brain pathology (Zurich, Switzerland) · 2002Article
- MRF4 protein expression in regenerating rat muscle.Journal of muscle research and cell motility · 2001Article
- A role for nitric oxide in muscle repair: nitric oxide-mediated activation of muscle satellite cells.Molecular biology of the cell · 2000Article
- Diagnostic protein expression in human muscle biopsies.Brain pathology (Zurich, Switzerland) · 2000Review
- Increased expression of dystrophin, beta-dystroglycan and adhalin in denervated rat muscles.Journal of muscle research and cell motility · 1996Article
- Overexpression of myogenin in muscles of transgenic mice: interaction with Id-1, negative crossregulation of myogenic factors, and induction of extrasynaptic acetylcholine receptor expression.Molecular and cellular biology · 1995Article
- Temporal expression of regulatory and structural muscle proteins during myogenesis of satellite cells on isolated adult rat fibers.Developmental biology · 1994Article
- Jun, Fos, MyoD1, and myogenin proteins are increased in skeletal muscle fiber nuclei after denervation.Acta neuropathologica · 1994Article
- Presymptomatic biochemical changes in hindlimb muscle of G93A human Cu/Zn superoxide dismutase 1 transgenic mouse model of amyotrophic lateral sclerosis.Biochimica et biophysica actaArticle
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1 author at 1 institution in 1 country.
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Abstract
After denervation, mRNA levels of the jun and fos protooncogenes and of the muscular differentiation factors myoD1 and myogenin are increased. Here, immunohistochemistry was used (a) to show that this increase in mRNA is followed by an increase in the transcription factor proteins, and (b) to determine which cell populations in skeletal muscle express these factors after denervation. Rat diaphragms were denervated and analyzed after periods of 90 min-8 days. An increase in Fos and Jun as well as MyoD1 and Myogenin immunoreactivity was found after 2-2.5 days of denervation. Fos, MyoD1, and Myogenin immunoreactivity was mostly confined to muscle cell nuclei, whereas Jun antibodies stained muscle cell and some interstitial cell nuclei. A selective expression of any of the four transcription factors in muscle cell nuclei closely associated with motor endplates could not be detected in either denervated or innervated muscle at any time point examined, indicating that synaptic and extrasynaptic muscle cell nuclei are activated simultaneously after denervation. These results suggest that a genetic program which includes protooncogenes and myogenic differentiation factors is activated in skeletal muscle after denervation.
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