ArticleNaunyn-Schmiedeberg's archives of pharmacology1994
P2-purinoceptor antagonists discriminate three contraction-mediating receptors for ATP in rat vas deferens.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 72 citations in OpenAlex.
- P2-purinoceptor antagonists: II. Blockade of P2-purinoceptor subtypes and ecto-nucleotidases by compounds related to Evans blue and trypan blue.Naunyn-Schmiedeberg's archives of pharmacology · 1996Article
- P2-purinoceptor antagonists: I. Blockade of P2-purinoceptor subtypes and ecto-nucleotidases by small aromatic isothiocyanato-sulphonates.Naunyn-Schmiedeberg's archives of pharmacology · 1996Article
- P2-purinoceptor antagonists: III. Blockade of P2-purinoceptor subtypes and ecto-nucleotidases by compounds related to suramin.Naunyn-Schmiedeberg's archives of pharmacology · 1996Article
- Evidence for two distinct P2-purinoceptors subserving contraction of the rat anococcygeus smooth muscle.British journal of pharmacology · 1996Article
- Discrimination by PPADS between endothelial P2Y- and P2U-purinoceptors in the rat isolated mesenteric arterial bed.British journal of pharmacology · 1996Article
- P2-purinoceptors mediating spasm of the isolated uterus of the non-pregnant guinea-pig.British journal of pharmacology · 1996Article
- Evaluation of P2-purinoceptor antagonists at two relaxation-mediating P2-purinoceptors in guinea-pig taenia coli.Naunyn-Schmiedeberg's archives of pharmacology · 1996Article
- Failure of tyramine to release neuronal ATP as a cotransmitter of noradrenaline in the guinea-pig vas deferens.Naunyn-Schmiedeberg's archives of pharmacology · 1996Article
- New insights on P2X purinoceptors.Naunyn-Schmiedeberg's archives of pharmacology · 1995Review
- Failure of the putative neuropeptide Y antagonists, benextramine and PYX-2, to inhibit Y2 receptors in rat isolated prostatic vas deferens.British journal of pharmacology · 1995Article
- Reactive red 2: a P2y-selective purinoceptor antagonist and an inhibitor of ecto-nucleotidase.Naunyn-Schmiedeberg's archives of pharmacology · 1995Article
- Inhibitory action of PPADS on relaxant responses to adenine nucleotides or electrical field stimulation in guinea-pig taenia coli and rat duodenum.British journal of pharmacology · 1995Article
- The selective P2X purinoceptor agonist, beta,gamma-methylene-L-adenosine 5'-triphosphate, discriminates between smooth muscle and neuronal P2X purinoceptors.Naunyn-Schmiedeberg's archives of pharmacology · 1995Article
- Functional consequences of inhibition of nucleotide breakdown in rat vas deferens: a study with Evans blue.Naunyn-Schmiedeberg's archives of pharmacology · 1995Article
- Effects of suramin on contractions of the guinea-pig vas deferens induced by analogues of adenosine 5'-triphosphate.British journal of pharmacology · 1995Article
- Inhibition by suramin and reactive blue 2 of GABA and glutamate receptor channels in rat hippocampal neurons.Naunyn-Schmiedeberg's archives of pharmacology · 1995Article
- Co-transmitter mediated facilitation by sympathetic nerve stimulation of evoked acetylcholine release from the rabbit perfused atria preparation.Naunyn-Schmiedeberg's archives of pharmacology · 1995Article
- Electrically-evoked release of taurine in the rat vas deferens: evidence for a purinoceptor-mediated effect.Naunyn-Schmiedeberg's archives of pharmacology · 1995Article
- Evidence for the presence of both pre- and postjunctional P2-purinoceptor subtypes in human isolated urinary bladder.British journal of pharmacology · 1995Article
- The fade of the purinergic neurogenic contraction of the guinea-pig vas deferens: analysis of possible mechanisms.Naunyn-Schmiedeberg's archives of pharmacology · 1994Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The sites of action at which ATP elicits contraction of the rat vas deferens were studied by means of the P2-purinoceptor antagonists pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid (iso-PPADS), suramin and reactive blue 2. Increasing concentrations of iso-PPADS (up to 1 mM), suramin (up to 1 mM) and reactive blue 2 (up to 320 microM) reduced and eventually abolished contractions elicited by the P2x-purinoceptor-selective agonist alpha,beta-methylene ATP 3 microM with IC50 values of 2.1, 10.1 and 27.0 microM, respectively. In contrast, iso-PPADS and suramin caused only a partial inhibition of contractions elicited by ATP 1 mM, maximal reduction by about 40%, IC50 values 1.3 and 5.0 microM, respectively; reactive blue 2 did not change ATP-induced contractions. In tissues exposed to iso-PPADS 320 microM throughout, increasing concentrations of reactive blue 2 or suramin decreased contractions elicited by ATP 1 mM, IC50 values 2.6 and 14.5 microM, respectively. In tissues exposed to suramin 320 microM throughout, increasing concentrations of iso-PPADS decreased contractions elicited by ATP 1 mM, IC50 37.9 microM, whereas reactive blue 2 slightly enhanced these contractions. In tissues exposed to reactive blue 2 100 microM throughout, increasing concentrations of iso-PPADS reduced contractions elicited by ATP 1 mM, IC50 26.6 microM, whereas suramin caused no change. Pre-exposure to alpha,beta-methylene ATP 1 microM to desensitize P2x-purinoceptors reduced the response to ATP 1 mM by 91% in otherwise untreated tissues, but did not reduce the response to ATP 1 mM in tissues exposed throughout to iso-PPADS 320 microM, suramin 320 microM or reactive blue 2 100 microM.(ABSTRACT TRUNCATED AT 250 WORDS)
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