ArticleMolecular and cellular biology1994
FTZ-F1-related orphan receptors in Xenopus laevis: transcriptional regulators differentially expressed during early embryogenesis.
Article in Molecular and cellular biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 76 citations in OpenAlex.
- Exploring the Expanding Role of Nuclear Receptor LRH-1/NR5A2 in Cell Biology and Immunity.International journal of cell biology · 2026Review
- Solution Nuclear Magnetic Resonance Studies of the Ligand-Binding Domain of an Orphan Nuclear Receptor Reveal a Dynamic Helix in the Ligand-Binding Pocket.Biochemistry · 2018Article
- Regulation of germ layer formation by pluripotency factors during embryogenesis.Cell & bioscience · 2013Article
- Molecular cloning and expression analysis of fushi tarazu factor 1 in the brain of air-breathing catfish, Clarias gariepinus.PloS one · 2011Article
- Identification of embryonic pancreatic genes using Xenopus DNA microarrays.Developmental dynamics : an official publication of the American Association of Anatomists · 2009Article
- Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis.Molecular endocrinology (Baltimore, Md.) · 2008Article
- Multiple mechanisms promote the retained expression of gene duplicates in the tetraploid frog Xenopus laevis.PLoS genetics · 2006Article
- Gene duplication, gene loss and evolution of expression domains in the vertebrate nuclear receptor NR5A (Ftz-F1) family.The Biochemical journal · 2005Article
- Pancreatic-duodenal homeobox 1 regulates expression of liver receptor homolog 1 during pancreas development.Molecular and cellular biology · 2003Article
- FTZ-Factor1 and Fushi tarazu interact via conserved nuclear receptor and coactivator motifs.The EMBO journal · 2001Article
- Zebrafish ftz-f1 gene has two promoters, is alternatively spliced, and is expressed in digestive organs.The Biochemical journal · 2000Article
- CPF: an orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7alpha-hydroxylase gene.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- The alpha1-fetoprotein locus is activated by a nuclear receptor of the Drosophila FTZ-F1 family.Molecular and cellular biology · 1996Article
- A functional Rev-erb alpha responsive element located in the human Rev-erb alpha promoter mediates a repressing activity.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Transactivation of a cellular promoter by the NS1 protein of the parvovirus minute virus of mice through a putative hormone-responsive element.Journal of virology · 1996Article
- Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Orphan receptors of the FTZ-F1-related group of nuclear receptors (xFF1r) were identified in Xenopus laevis by isolation of cDNAs from a neurula stage library. Two cDNAs were found, which encode full length, highly related receptor proteins, xFF1rA and B, whose closet relative known so far is the murine LRH-1 orphan receptor. xFF1rA protein expressed by a recombinant vaccinia virus system specifically binds to FTZ-F1 response elements (FRE; PyCAAGGPyCPu). In cotransfection studies, xFF1rA constitutively activates transcription, in a manner dependent on the number of FREs. The amounts of at least four mRNAs encoding full-length receptors greatly increase between gastrula and early tailbud stages and decrease at later stages. At early tailbud stages, xFTZ-F1-related antigens are found in all nuclei of the embryo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.